Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6602798 | 0.86 | KDM4E (0.58) | HPGDALDH1A1KDM4ENPSR1MEN1 | |
| SCHEMBL29039907 | 0.85 | HPGD (0.54) | HPGDALDH1A1KDM4ENPSR1NCEH1 | |
| SCHEMBL6605181 | 0.83 | HPGD (0.56) | HPGDALDH1A1KDM4ENPSR1NCEH1 | |
| SCHEMBL10559440 | 0.81 | ALDH1A1 (0.59) | HPGDALDH1A1KDM4ENPSR1NCEH1 | |
| SCHEMBL2777918 | 0.81 | MEN1 (0.60) | HPGDALDH1A1KDM4ENPSR1NCEH1 | |
| SCHEMBL17509446 | 0.81 | TSHR (0.48) | HPGDALDH1A1KDM4ENPSR1HSD17B10 | |
| SCHEMBL6229441 | 0.80 | ALDH1A1 (0.52) | HPGDALDH1A1KDM4ENPSR1NCEH1 | |
| SCHEMBL6605254 | 0.79 | ALDH1A1 (0.51) | HPGDALDH1A1KDM4ENPSR1NCEH1 | |
| SCHEMBL27718061 | 0.78 | ALDH1A1 (0.55) | HPGDALDH1A1KDM4ENPSR1NCEH1 | |
| SCHEMBL1648076 | 0.77 | NCEH1 (0.59) | HPGDALDH1A1KDM4ENPSR1NCEH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119551-B1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | EP | disclosed |
| EP-1433783-A2 | Naphthalenecarboxamides as tachykinin receptor antagonists | AstraZeneca AB (SE) | 2004-06-30 | — | — | EP | disclosed |
| EP-1119551-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000020389-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-04-13 | — | — | WO | disclosed |