Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 4/20 | 0.58 |
| ▸ | RXRB | P28702 | 3/20 | 0.58 |
| ▸ | RXRG | P48443 | 2/20 | 0.58 |
| ▸ | PTGER1 | P34995 | 8/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | FEN1 | P39748 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.46 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.46 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5099618 | 0.80 | RXRA (0.78) | RXRARXRBRXRGPTGER1MCL1 | |
| SCHEMBL6604669 | 0.80 | RXRA (0.62) | RXRARXRBRXRGPTGER1MCL1 | |
| SCHEMBL3759214 | 0.80 | RXRA (0.88) | RXRARXRBRXRGPTGER1MCL1 | |
| SCHEMBL6606655 | 0.77 | RXRA (0.69) | RXRARXRBRXRGPTGER1MCL1 | |
| SCHEMBL6605970 | 0.75 | RXRA (0.66) | RXRARXRBRXRGPTGER1MCL1 | |
| SCHEMBL5096132 | 0.72 | PTGER1 (1.00) | RXRARXRBRXRGPTGER1PTGER4 | |
| SCHEMBL5620525 | 0.71 | PTGER1 (0.77) | RXRARXRBRXRGPTGER1MAP4K4 | |
| SCHEMBL5100155 | 0.71 | PTGER1 (1.00) | RXRARXRBRXRGPTGER1FEN1 | |
| SCHEMBL16321220 | 0.71 | MAP4K4 (0.67) | RXRARXRBRXRGPTGER1MAP4K4 | |
| SCHEMBL15923280 | 0.70 | RXRA (0.68) | RXRARXRBRXRGPTGER1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216238-B1 | CARBOXYLIC ACIDS AND ACYLSULFONAMIDES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK FROSST CANADA INC (CA) | 2004-02-18 | — | — | EP | claimed |
| US-6452000-B2 | ALKYLATION; ACYLATION; CYCLIZATION; IMINATION; USEFUL AS HIV PROTEASE INHIBITORS | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-09-17 | — | — | US | claimed |
| US-20010020093-A1 | Preparation of asymmetric cyclic ureas through a monoacylated diamine intermeidate | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2001-09-06 | — | — | US | claimed |
| US-6218534-B1 | Preparation of asymmetric cyclic ureas through a monoacylated diamine intermediate | DUPONT PHARMACEUTICALS COMPANY | 2001-04-17 | — | — | US | claimed |
| EP-1216238-B1 | CARBOXYLIC ACIDS AND ACYLSULFONAMIDES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK FROSST CANADA INC (CA) | 2004-02-18 | — | — | EP | disclosed |
| US-6452000-B2 | ALKYLATION; ACYLATION; CYCLIZATION; IMINATION; USEFUL AS HIV PROTEASE INHIBITORS | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-09-17 | — | — | US | disclosed |
| US-6369084-B1 | PROSTAGLANDIN MEDIATED DISEASES | MERCK FROSST CANADA & CO. (CA) | 2002-04-09 | — | — | US | disclosed |
| US-20010020093-A1 | Preparation of asymmetric cyclic ureas through a monoacylated diamine intermeidate | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2001-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010020093-A1 | Preparation of asymmetric cyclic ureas through a monoacylated diamine intermeidate | IMPDH1, IDE, DIMT1 | RXRA 4552/4885RXRB 4699/4885RXRG 4775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.