Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 4/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 2/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL396776 | 0.87 | IMPDH2 (0.46) | IMPDH2ARASH1LCLK1CDK5 | |
| SCHEMBL27694047 | 0.81 | IMPDH2 (0.42) | IMPDH2ARASH1LCLK1CDK5 | |
| SCHEMBL5646170 | 0.81 | GPR84 (0.50) | HTR2AMEN1KMT2A | |
| SCHEMBL9011480 | 0.81 | GPR84 (0.50) | HTR2A | |
| SCHEMBL2577669 | 0.80 | AR (0.58) | IMPDH2ARASH1LCLK1CDK5 | |
| SCHEMBL27694046 | 0.76 | HTR2A (0.47) | IMPDH2KIF11HTR2AMEN1KMT2A | |
| SCHEMBL19667114 | 0.76 | SPR (0.44) | KIF11PARP1MEN1KMT2AKDM4E | |
| SCHEMBL28338789 | 0.76 | IMPDH2 (0.38) | IMPDH2ARASH1LCLK1CDK5 | |
| SCHEMBL7192679 | 0.76 | ATM (0.50) | IMPDH2HTR2AMEN1KMT2AKDM4E | |
| SCHEMBL395010 | 0.73 | ATM (0.52) | IMPDH2ASH1LCLK1CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1435949-A1 | 2' -METHYL-5-(1,3,4-OXADIAZOL-2-YL)-1,1'-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003032986-A1 | 2' -METHYL-5-(1,3,4-OXADIAZOL-2-YL)-1,1'-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-04-24 | — | — | WO | disclosed |