Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6881721 | 0.91 | KMT2A (0.42) | MAPTNPSR1HCAR3KMT2AMEN1 | |
| SCHEMBL6164705 | 0.86 | RAB9A (0.37) | MAPTNPSR1KMT2AMEN1RAB9A | |
| SCHEMBL6609128 | 0.81 | DYRK1A (0.37) | MAPTALDH1A1SMN1; SMN2MAPK1KDM4E | |
| SCHEMBL5562862 | 0.77 | RAB9A (0.41) | MAPTNPSR1HCAR3KMT2AMEN1 | |
| SCHEMBL6607273 | 0.73 | MAPT (0.45) | MAPTNPSR1HCAR3KMT2AMEN1 | |
| SCHEMBL6607646 | 0.73 | MAPT (0.45) | MAPTNPSR1HCAR3KMT2ARAB9A | |
| SCHEMBL6607834 | 0.73 | MAPT (0.45) | MAPTHCAR3KMT2AMEN1RAB9A | |
| SCHEMBL6608184 | 0.72 | MAPT (0.42) | MAPTNPSR1HCAR3KMT2ARAB9A | |
| SCHEMBL6611884 | 0.72 | HDAC1 (0.40) | MAPTRAB9ASMN1; SMN2HTTKDM4E | |
| SCHEMBL5106497 | 0.69 | CHRM3 (0.48) | MAPTKMT2AMEN1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379511-A1 | DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002083652-A1 | DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2002-10-24 | — | — | WO | disclosed |