Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.40 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.39 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5557485 | 0.83 | RAB9A (0.42) | MAPTALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL6881721 | 0.82 | KMT2A (0.42) | MAPTALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL1067339 | 0.81 | CXCR2 (0.43) | MAPTALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL1067337 | 0.81 | CXCR2 (0.43) | MAPTALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL27615856 | 0.78 | APP (0.42) | MAPTALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL6609242 | 0.78 | MEN1 (0.47) | MAPTALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL6608004 | 0.78 | KMT2A (0.39) | MAPTALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL5606205 | 0.74 | MAPT (0.49) | MAPTALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL7707281 | 0.73 | SMN1; SMN2 (0.45) | MAPTALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL6607277 | 0.73 | MAPT (0.39) | MAPTALDH1A1MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379511-A1 | DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002083652-A1 | DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2002-10-24 | — | — | WO | disclosed |