Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | KAT6A | Q92794 | 6/20 | 0.56 |
| ▸ | GLS | O94925 | 2/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | PLOD2 | O00469 | 3/20 | 0.42 |
| ▸ | PLOD3 | O60568 | 3/20 | 0.42 |
| ▸ | PLOD1 | Q02809 | 3/20 | 0.42 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.42 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.41 |
| ▸ | TEK | Q02763 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12883023 | 0.84 | LMNA (0.51) | LMNAKAT6AGLSFFAR4PLOD2 | |
| SCHEMBL29488339 | 0.83 | KAT6A (0.59) | LMNAKAT6AFFAR4ERCC1ERCC4 | |
| SCHEMBL940668 | 0.83 | KAT6A (0.59) | LMNAKAT6AFFAR4ERCC1ERCC4 | |
| SCHEMBL24247727 | 0.82 | KAT6A (0.49) | LMNAKAT6AGLSFFAR4PLOD2 | |
| SCHEMBL6623169 | 0.82 | NOTUM (0.54) | LMNAKAT6APLOD2PLOD3PLOD1 | |
| SCHEMBL5929327 | 0.82 | KAT6A (0.56) | LMNAKAT6AGLSFFAR4ERCC1 | |
| SCHEMBL6163346 | 0.81 | KAT6A (0.47) | LMNAKAT6AGLSPLOD2PLOD3 | |
| SCHEMBL31173853 | 0.80 | LMNA (0.56) | LMNAKAT6AERCC1ERCC4ALDH1A1 | |
| SCHEMBL2161445 | 0.80 | LMNA (0.56) | LMNAKAT6AERCC1ERCC4ALDH1A1 | |
| SCHEMBL16220632 | 0.79 | KAT6A (0.54) | LMNAKAT6AERCC1ERCC4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1268626-C | Dihydro-benzo(b)(1,4)diazepin-2-one derivatives as mglur2 antagonists I | HOFFMANN LA ROCHE (CH) | 2006-08-09 | — | — | CN | disclosed |
| CN-1522252-A | Dihydro-benzo(b)(1,4)diazepin-2-one derivatives as mglur2 antagonists I | - | 2004-08-18 | — | — | CN | disclosed |
| EP-1379511-A1 | DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002083652-A1 | DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2002-10-24 | — | — | WO | disclosed |