Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 5/20 | 0.44 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 3/20 | 0.38 |
| ▸ | PRCP | P42785 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6610212 | 0.99 | MAPT (0.58) | MAPTACHEHTR2CHTR2AHTR2B | |
| SCHEMBL6608441 | 0.82 | MAPT (0.70) | MAPTACHEHTR2CHTR2AHTR2B | |
| Hydrochloric Acid SCHEMBL6610702 | 0.81 | MAPT (0.72) | MAPTACHEHTR2CHTR2AHTR2B | |
| SCHEMBL6608544 | 0.80 | ACHE (0.47) | MAPTACHEHTR2CHTR2AHTR2B | |
| Hydrochloric Acid SCHEMBL6607875 | 0.78 | ACHE (0.46) | MAPTACHEHTR2CHTR2AHTR2B | |
| SCHEMBL6607643 | 0.75 | MAPT (0.49) | MAPTHTR2CHTR2AHTR2BCYP3A4 | |
| SCHEMBL11839438 | 0.74 | MAPT (0.60) | MAPTACHEHTR2CHTR2AHTR2B | |
| SCHEMBL6611810 | 0.73 | MAPT (0.97) | MAPTACHEHTR2CHTR2AHTR2B | |
| SCHEMBL11831047 | 0.72 | MAPT (0.56) | MAPTACHEHTR2CHTR2AHTR2B | |
| SCHEMBL6607761 | 0.69 | MAPT (0.48) | MAPTHTR2CHTR2AHTR2BCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0997462-A1 | NOVEL NAPHTHYRIDINE DERIVATIVES OR SALTS THEREOF | Nippon Kayaku Kabushiki Kaisha (JP) | 2000-05-03 | — | — | EP | claimed |
| EP-0997462-B1 | NOVEL NAPHTHYRIDINE DERIVATIVES OR SALTS THEREOF | NIPPON KAYAKU KK (JP) | 2004-12-22 | — | — | EP | disclosed |
| US-6294547-B1 | Naphthyridine deratives or salts thereof | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2001-09-25 | — | — | US | disclosed |
| EP-0997462-A1 | NOVEL NAPHTHYRIDINE DERIVATIVES OR SALTS THEREOF | Nippon Kayaku Kabushiki Kaisha (JP) | 2000-05-03 | — | — | EP | disclosed |