Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 6/20 | 0.51 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | MYC | P01106 | 2/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.40 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.40 |
| ▸ | SCN2B | O60939 | 1/20 | 0.40 |
| ▸ | SCN1A | P35498 | 1/20 | 0.40 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6609151 | 0.83 | HDAC2 (0.47) | PTPN1 | |
| SCHEMBL31331542 | 0.80 | SCN9A (0.64) | SCN9AP4HTMPTPN1SCN3AMAP4K4 | |
| SCHEMBL6607417 | 0.78 | SCN9A (0.60) | SCN9AP4HTMPTPN1SCN5AMAP4K4 | |
| SCHEMBL6611172 | 0.77 | MAPT (0.57) | — | |
| SCHEMBL6608198 | 0.76 | KEAP1 (0.53) | — | |
| SCHEMBL6642630 | 0.76 | TSHR (0.53) | PTPN1 | |
| SCHEMBL364110 | 0.76 | HDAC3 (0.58) | SCN9AP4HTMPTPN1SCN5ASCN3A | |
| SCHEMBL10469452 | 0.75 | TSHR (0.48) | BCL2L1 | |
| Hydrochloric Acid SCHEMBL4438185 | 0.75 | P4HTM (0.56) | SCN9AP4HTMPTPN1SCN5ASCN3A | |
| SCHEMBL16618535 | 0.74 | SCN9A (0.52) | SCN9AP4HTMPTPN1SCN5AMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1423386-A1 | THIOPHENYLTHIOPYRANE DIOXIDES AS MMP OR TNF-ALPHA INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-06-02 | — | — | EP | claimed |
| WO-2003022842-A1 | THIOPHENYLTHIOPYRANE DIOXIDES AS MMP OR TNF-ALPHA INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-03-20 | — | — | WO | claimed |