Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | APP | P05067 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | INSR | P06213 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.55 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | SNCA | P37840 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3826536 | 0.94 | MEN1 (0.48) | MEN1KMT2AMAPTAPPRAB9A | |
| SCHEMBL6609826 | 0.78 | NOX1 (0.51) | MEN1KMT2AMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL3824183 | 0.73 | NOX1 (0.45) | MEN1KMT2AMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL476579 | 0.72 | MEN1 (1.00) | MEN1KMT2AMAPTAPPRAB9A | |
| SCHEMBL29413750 | 0.72 | MEN1 (1.00) | MEN1KMT2AMAPTAPPRAB9A | |
| SCHEMBL29433017 | 0.72 | MEN1 (1.00) | MEN1KMT2AMAPTAPPRAB9A | |
| SCHEMBL476578 | 0.72 | MEN1 (1.00) | MEN1KMT2AMAPTAPPRAB9A | |
| SCHEMBL15949927 | 0.72 | MEN1 (0.62) | MEN1KMT2AMAPTAPPRAB9A | |
| SCHEMBL11310551 | 0.72 | MEN1 (0.62) | MEN1KMT2AMAPTAPPRAB9A | |
| Bromide SCHEMBL8389953 | 0.71 | MEN1 (0.97) | MEN1KMT2AMAPTAPPRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0999835-A4 | IMIDAZOLE DERIVATIVES AS MDR MODULATORS | ONTOGEN CORP (US) | 2004-08-25 | — | — | EP | disclosed |
| EP-0999835-A1 | IMIDAZOLE DERIVATIVES AS MDR MODULATORS | Ontogen Corporation (US) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999002155-A1 | IMIDAZOLE DERIVATIVES AS MDR MODULATORS | ONTOGEN CORPORATION (US) | 1999-01-21 | — | — | WO | disclosed |