Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | RBP4 | P02753 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6164712 | 0.85 | L3MBTL1 (0.38) | RXFP1MAPK9MAPK10POLBRORC | |
| SCHEMBL6871029 | 0.84 | ALDH1A1 (0.39) | SMN1; SMN2NOTUM | |
| SCHEMBL7462988 | 0.79 | CYP17A1 (0.37) | RXFP1HCRTR1HCRTR2IDO1 | |
| SCHEMBL7704394 | 0.78 | ALDH1A1 (0.36) | POLBLMNAIDO1 | |
| SCHEMBL6164277 | 0.78 | L3MBTL1 (0.36) | MAPK9MAPK10POLBRORCNOTUM | |
| SCHEMBL6166867 | 0.77 | L3MBTL1 (0.36) | MAPK9MAPK10POLBRORCNOTUM | |
| SCHEMBL6166140 | 0.77 | L3MBTL1 (0.38) | RXFP1POLBLMNA | |
| SCHEMBL5563839 | 0.75 | SCN9A (0.44) | POLBBRD9 | |
| SCHEMBL6166873 | 0.75 | L3MBTL1 (0.42) | RXFP1POLBLMNARORCBRD9 | |
| SCHEMBL7220987 | 0.75 | ABL1 (0.43) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379511-A1 | DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002083652-A1 | DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2002-10-24 | — | — | WO | disclosed |