Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 15/20 | 0.45 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6595816 | 0.89 | GCK (0.53) | GCKFFAR2KCNH2POLB | |
| SCHEMBL2649633 | 0.88 | GCK (0.46) | GCKFFAR2KCNH2 | |
| SCHEMBL2647572 | 0.86 | GCK (0.46) | GCKPOLB | |
| SCHEMBL2647650 | 0.85 | GCK (0.48) | GCKFFAR2KCNH2 | |
| SCHEMBL2648600 | 0.84 | GCK (0.47) | GCKFFAR2KCNH2 | |
| SCHEMBL6593978 | 0.84 | GCK (0.48) | GCKFFAR2KCNH2POLB | |
| SCHEMBL6563774 | 0.83 | FFAR2 (0.56) | GCKFFAR2KCNH2 | |
| SCHEMBL6561839 | 0.83 | GCK (0.48) | GCKFFAR2KCNH2POLB | |
| SCHEMBL2648137 | 0.83 | LTC4S (0.52) | GCKPOLB | |
| SCHEMBL6596857 | 0.82 | GCK (0.51) | GCKFFAR2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1282611-B1 | SUBSTITUTED PHENYLACETAMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2004-10-20 | — | — | EP | claimed |