Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | FPR1 | P21462 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7140985 | 0.88 | ALDH1A1 (0.44) | SMN1; SMN2GAAALDH1A1LMNAHPGD | |
| SCHEMBL7704803 | 0.85 | ALDH1A1 (0.41) | SMN1; SMN2GAAALDH1A1LMNAMEN1 | |
| SCHEMBL7139674 | 0.74 | ALDH1A1 (0.44) | SMN1; SMN2GAAALDH1A1LMNAHPGD | |
| SCHEMBL6607834 | 0.73 | MAPT (0.45) | SMN1; SMN2GAAALDH1A1LMNAMEN1 | |
| SCHEMBL7138095 | 0.73 | ALDH1A1 (0.37) | SMN1; SMN2ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL6166846 | 0.71 | MAPT (0.59) | SMN1; SMN2GAAALDH1A1LMNAMAPT | |
| SCHEMBL6881721 | 0.71 | KMT2A (0.42) | SMN1; SMN2ALDH1A1LMNAHPGDMEN1 | |
| SCHEMBL7145991 | 0.70 | ALDH1A1 (0.44) | SMN1; SMN2GAAALDH1A1LMNAHPGD | |
| SCHEMBL6074155 | 0.70 | SMN1; SMN2 (0.57) | SMN1; SMN2GAAALDH1A1LMNAHPGD | |
| SCHEMBL29948580 | 0.70 | SMN1; SMN2 (0.57) | SMN1; SMN2GAAALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224174-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001029011-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |