Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.51 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.51 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6606776 | 0.78 | HRH1 (0.56) | HTR2AHTR2CHRH1CACNA1G | |
| SCHEMBL6603889 | 0.78 | HTR2A (0.68) | HTR2AGRM2DRD2DRD1HTR2C | |
| SCHEMBL6606267 | 0.76 | HRH1 (0.64) | KCNH2HRH1 | |
| SCHEMBL6607904 | 0.74 | HRH1 (0.44) | KCNH2HRH1OPRK1SIGMAR1 | |
| SCHEMBL8279384 | 0.74 | HTR2A (0.62) | HTR2AKCNH2GRM2DRD2ADRA2B | |
| SCHEMBL6605503 | 0.73 | HRH1 (0.51) | HTR2AHTR2CHRH1CACNA1G | |
| SCHEMBL11103654 | 0.71 | CHRM3 (0.42) | HTR2AHTR2C | |
| SCHEMBL6603645 | 0.71 | HRH1 (0.41) | KCNH2HRH1CACNA1G | |
| SCHEMBL8008456 | 0.71 | HTR2A (0.60) | HTR2AKCNH2GRM2DRD2ADRA2B | |
| SCHEMBL7470355 | 0.70 | SIGMAR1 (0.43) | HTR2AKCNH2GRM2DRD2ADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756370-B1 | POTENT 5-HT2A RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2004-06-29 | — | — | US | disclosed |
| EP-1202966-B1 | PIPERIDINE ALCOHOLS | MERCK PATENT GMBH (DE) | 2004-06-09 | — | — | EP | disclosed |
| EP-1202966-A1 | PIPERIDINE ALCOHOLS | MERCK PATENT GmbH (DE) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001014332-A1 | PIPERIDINE ALCOHOLS | MERCK PATENT GMBH (DE) | 2001-03-01 | — | — | WO | disclosed |