Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PPIB | P23284 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.38 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.38 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6605355 | 0.88 | LMNA (0.51) | LMNATHRBMAPTALDH1A1 | |
| SCHEMBL6604906 | 0.85 | L3MBTL1 (0.50) | LMNATHRBL3MBTL1TP53ALDH1A1 | |
| SCHEMBL6605709 | 0.84 | GAA (0.44) | LMNATHRBFAAH | |
| SCHEMBL6606492 | 0.79 | LMNA (0.52) | LMNATHRBMAPT | |
| SCHEMBL6609494 | 0.78 | LMNA (0.51) | LMNATHRBMAPT | |
| SCHEMBL6512442 | 0.76 | LMNA (0.49) | LMNATHRBMAPTALDH1A1 | |
| SCHEMBL6607095 | 0.76 | LMNA (0.49) | LMNATHRBL3MBTL1MAPT | |
| SCHEMBL16277925 | 0.75 | CMA1 (0.43) | LMNAMAPTTP53 | |
| SCHEMBL6470981 | 0.75 | LMNA (0.47) | LMNATHRBMAPTTP53 | |
| SCHEMBL6607569 | 0.73 | LMNA (0.48) | LMNATHRBMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368327-B1 | BENZO THIADIAZINE MATRIX METALLOPROTEINASE INHIBITORS | WARNER LAMBERT CO (US) | 2004-10-20 | — | — | EP | claimed |