Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 5/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 6/20 | 0.39 |
| ▸ | PPARA | Q07869 | 5/20 | 0.39 |
| ▸ | VDR | P11473 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | TARBP2 | Q15633 | 2/20 | 0.38 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL821405 | 0.81 | PPARG (0.59) | PPARDPPARGPPARAKDM4EHPGD | |
| SCHEMBL5018050 | 0.76 | PPARG (0.57) | PPARDPPARGPPARAKDM4E | |
| SCHEMBL14382242 | 0.76 | KDM4E (0.47) | PPARDFFAR1GAAPPARGPPARA | |
| SCHEMBL31095026 | 0.75 | PPARG (0.50) | PPARDPPARGPPARAKDM4E | |
| SCHEMBL820892 | 0.75 | GAA (0.48) | PPARDFFAR1GAAPPARGPPARA | |
| SCHEMBL1553059 | 0.74 | VDR (0.46) | PPARDFFAR1PPARGPPARAVDR | |
| SCHEMBL13007421 | 0.73 | ALDH1A1 (0.44) | PPARDFFAR1PPARGPPARAKDM4E | |
| SCHEMBL14382241 | 0.73 | GAA (0.47) | PPARDFFAR1GAAVDRKDM4E | |
| SCHEMBL5814674 | 0.72 | KDM4E (0.57) | PPARDFFAR1PPARGPPARAKDM4E | |
| SCHEMBL4427114 | 0.72 | VDR (0.50) | PPARDFFAR1GAAPPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102757-B1 | SUBSTITUTED OXAZOLE AND THIAZOLE DERIVATIVES AS HPPAR GAMMA AND HPPAR ALPHA ACTIVATORS | GLAXO GROUP LTD (GB) | 2004-04-14 | — | — | EP | disclosed |
| EP-1102757-A1 | SUBSTITUTED OXAZOLE AND THIAZOLE DERIVATIVES AS HPPAR GAMMA AND HPPAR ALPHA ACTIVATORS | GLAXO GROUP LIMITED (GB) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000008002-A1 | SUBSTITUTED OXAZOLES AND THIAZOLES DERIVATIVES AS hPPAR GAMMA AND hPPAR ALPHA ACTIVATORS | GLAXO GROUP LIMITED (GB) | 2000-02-17 | — | — | WO | disclosed |