SCHEMBL821405

SCHEMBL821405

Cc1oc(-c2ccccc2)nc1CCOS(C)(=O)=O

nearest known ligand 0.59

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PPARG P37231 17/20 0.59
PPARA Q07869 14/20 0.59
KDM4E B2RXH2 1/20 0.58
PPARD Q03181 1/20 0.56
HRH3 Q9Y5N1 1/20 0.52
HPGD P15428 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5018050 0.92 PPARG (0.57) PPARGPPARAKDM4EPPARDHRH3
SCHEMBL31095026 0.91 PPARG (0.50) PPARGPPARAKDM4EPPARDHRH3
SCHEMBL6293717 0.89 PPARG (0.50) PPARGPPARAPPARDHPGD
SCHEMBL3578702 0.87 PPARG (0.55) PPARGPPARAKDM4EPPARD
SCHEMBL6601904 0.87 HSD17B10 (0.53) PPARGPPARAHPGD
SCHEMBL31095024 0.87 PPARG (0.46) PPARGPPARAKDM4EPPARD
SCHEMBL6293798 0.87 PPARA (0.53) PPARGPPARAPPARD
SCHEMBL31095004 0.87 KDM4E (0.52) PPARGPPARAKDM4EPPARDHRH3
SCHEMBL6293714 0.86 PPARG (0.64) PPARGPPARAPPARD
SCHEMBL5814674 0.86 KDM4E (0.57) PPARGPPARAKDM4EPPARDHRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 181 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3548023-A1 METHODS OF DOSE ADMINISTRATION FOR TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES T3D Therapeutics, Inc. (US) 2019-10-09 EP disclosed
WO-2018102358-A1 METHODS OF TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES BASED ON APOE4 GENOTYPE T3D THERAPEUTICS, INC. (US) 2018-06-07 WO disclosed
US-20180153859-A1 METHODS OF TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES BASED ON APOE4 GENOTYPE T3D THERAPEUTICS, INC. (US) 2018-06-07 US disclosed
US-20180153860-A1 METHODS OF DOSE ADMINISTRATION FOR TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES T3D THERAPEUTICS, INC. (US) 2018-06-07 US disclosed
WO-2018102399-A1 METHODS OF DOSE ADMINISTRATION FOR TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES T3D THERAPEUTICS, INC. (US) 2018-06-07 WO disclosed
WO-2018102399-A1 METHODS OF DOSE ADMINISTRATION FOR TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES T3D THERAPEUTICS, INC. (US) 2018-06-07 WO disclosed
US-20180153860-A1 METHODS OF DOSE ADMINISTRATION FOR TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES T3D THERAPEUTICS, INC. (US) 2018-06-07 US disclosed
US-20180153860-A1 METHODS OF DOSE ADMINISTRATION FOR TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES T3D THERAPEUTICS, INC. (US) 2018-06-07 US disclosed
US-20180153859-A1 METHODS OF TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES BASED ON APOE4 GENOTYPE T3D THERAPEUTICS, INC. (US) 2018-06-07 US disclosed
US-20180153859-A1 METHODS OF TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES BASED ON APOE4 GENOTYPE T3D THERAPEUTICS, INC. (US) 2018-06-07 US disclosed
US-20010039352-A1 Production method of isoxazolidinedione compound ANDO KOJI (JP) 2001-11-08 US disclosed
US-6248897-B1 FROM BETA-METHYL L-ASPARTATE JAPAN TOBACCO INC. (JP) 2001-06-19 US disclosed
WO-2001021602-A1 OXA- AND THIAZOLE DERIVATIVES USEFUL AS ANTIDIABETIC AND ANTIOBESITY AGENTS BRISTOL-MYERS SQUIBB COMPANY (US) 2001-03-29 WO disclosed
CN-1272109-A Method for producing isoxazolidinedione compound JAPAN TOBACCO INC (JP) 2000-11-01 CN disclosed
JP-2000143642-A PRODUCTION OF METHANESULFONATE COMPOUND JAPAN TOBACCO INC 2000-05-26 JP disclosed
JP-2000143643-A PRODUCTION OF BENZYLIDENE COMPOUND JAPAN TOBACCO INC 2000-05-26 JP disclosed
EP-0992503-A1 PROCESS FOR PRODUCING ISOOXAZOLIDINEDIONE COMPOUND JAPAN TOBACCO INC. (JP) 2000-04-12 EP disclosed
US-6043366-A USEFUL IN TREATING DISORDERS INVOLVING THE ORPHANIN FQ(A SEVENTEEN AMINO ACID LONG PEPTIDE) RECEPTOR. HOFFMAN-LA ROCHE INC. (US) 2000-03-28 US disclosed
CN-1233241-A Propionic acid derivatives and uses thereof JAPAN TOBACCO INC (JP) 1999-10-27 CN disclosed
EP-0921125-A1 1,3,8-Triaza-spiro 4,5 decan-4-on derivatives F. HOFFMANN-LA ROCHE AG (CH) 1999-06-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180153859-A1 METHODS OF TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES BASED ON APOE4 GENOTYPE CHRNA2, ACACA, CHAT PPARG 988/4885PPARA 534/4885KDM4E 4364/4885
US-20010039352-A1 Production method of isoxazolidinedione compound DDO, GPR119, ALDH7A1 PPARG 1061/4885PPARA 661/4885KDM4E 632/4885
US-20180153860-A1 METHODS OF DOSE ADMINISTRATION FOR TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES CHAT, ACHE, CHRNA2 PPARG 621/4885PPARA 516/4885KDM4E 3937/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.