Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CCR2 | P41597 | 3/20 | 0.50 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6180658 | 0.79 | CCR4 (0.69) | KDM4ETSHRGAAALDH1A1KMT2A | |
| SCHEMBL9967942 | 0.78 | KDM4E (0.58) | KDM4ETSHRGAAALDH1A1HPGD | |
| SCHEMBL5102415 | 0.77 | CCR5 (0.57) | KDM4EGAAALDH1A1HPGDKMT2A | |
| SCHEMBL2303166 | 0.77 | KDM4E (0.62) | KDM4EGAAALDH1A1HPGDKMT2A | |
| SCHEMBL4376658 | 0.76 | PTGDR2 (0.66) | KDM4EPTGDR2TSHRGAAALDH1A1 | |
| SCHEMBL8840340 | 0.76 | KDM4E (0.69) | KDM4ETSHRGAAALDH1A1HPGD | |
| SCHEMBL2422507 | 0.74 | KDM4E (0.70) | KDM4ETSHRGAAALDH1A1HPGD | |
| SCHEMBL9967998 | 0.73 | PKM (0.56) | KDM4ETSHRGAAALDH1A1HPGD | |
| SCHEMBL9967883 | 0.73 | CCR2 (0.49) | KDM4ETSHRGAAALDH1A1KMT2A | |
| SCHEMBL9931283 | 0.73 | CCR2 (0.67) | KDM4ETSHRCCR2NFKBIARELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458715-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003051870-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2003-06-26 | — | — | WO | disclosed |