Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6606751 | 0.85 | MEN1 (0.44) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL7674231 | 0.84 | MEN1 (0.37) | MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL6608621 | 0.82 | GPR119 (0.53) | GPR119NAMPTKDM4ETHRBMAPT | |
| SCHEMBL2102993 | 0.77 | GPR119 (0.53) | GPR119NAMPTKDM4ETHRBMAPT | |
| SCHEMBL30749320 | 0.77 | GPR119 (0.53) | GPR119NAMPTKDM4ETHRBMAPT | |
| SCHEMBL8332423 | 0.77 | GPR119 (0.49) | GPR119NAMPTKDM4ETHRBMAPT | |
| SCHEMBL3436365 | 0.76 | GPR119 (0.58) | GPR119NAMPTKDM4ETHRBMAPT | |
| Hydrochloric Acid SCHEMBL6604954 | 0.76 | HTR2C (0.48) | — | |
| SCHEMBL4854592 | 0.76 | MEN1 (0.64) | GPR119NAMPTMAPTALDH1A1MEN1 | |
| SCHEMBL4682164 | 0.75 | GPR119 (0.41) | GPR119NAMPTKDM4ETHRBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119551-B1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | EP | disclosed |
| EP-1433783-A2 | Naphthalenecarboxamides as tachykinin receptor antagonists | AstraZeneca AB (SE) | 2004-06-30 | — | — | EP | disclosed |
| EP-1119551-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000020389-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-04-13 | — | — | WO | disclosed |