Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | RBP4 | P02753 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6608348 | 0.85 | GPR119 (0.46) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7674231 | 0.85 | MEN1 (0.37) | MEN1KMT2ARBP4ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL6604954 | 0.81 | HTR2C (0.48) | — | |
| SCHEMBL6605558 | 0.78 | MEN1 (0.47) | MEN1KMT2ARBP4ALDH1A1MAPT | |
| SCHEMBL2637185 | 0.72 | MEN1 (0.77) | MEN1KMT2AALDH1A1MAPTNPSR1 | |
| SCHEMBL27223605 | 0.72 | MEN1 (0.47) | MEN1KMT2ARBP4ALDH1A1MAPT | |
| SCHEMBL2101664 | 0.71 | RBP4 (0.47) | MEN1KMT2ARBP4ALDH1A1MAPT | |
| SCHEMBL27900121 | 0.70 | TRPV1 (0.55) | MEN1KMT2ARBP4ALDH1A1TRPV1 | |
| SCHEMBL750673 | 0.70 | RBP4 (0.55) | MEN1KMT2ARBP4ALDH1A1MAPT | |
| SCHEMBL4678772 | 0.70 | KMT2A (0.36) | MEN1KMT2ARBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119551-B1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | EP | disclosed |
| EP-1433783-A2 | Naphthalenecarboxamides as tachykinin receptor antagonists | AstraZeneca AB (SE) | 2004-06-30 | — | — | EP | disclosed |