SCHEMBL6608474

SCHEMBL6608474

CNc1nc(Nc2ccc3ccccc3c2)nc(N(CCC2OCCO2)C2CCN(C)CC2)n1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDH2 P48735 2/20 0.38
L3MBTL1 Q9Y468 2/20 0.35
GAA P10253 1/20 0.35
EHMT2 Q96KQ7 1/20 0.35
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
EPHX2 P34913 1/20 0.34
TNIK Q9UKE5 1/20 0.34
MAP4K1 Q92918 2/20 0.33
CCNA2 P20248 1/20 0.33
CDK2 P24941 1/20 0.33
CCNA1 P78396 1/20 0.33
HTR6 P50406 1/20 0.33
PIM1 P11309 1/20 0.32
CDK4 P11802 1/20 0.32
CCND3 P30281 1/20 0.32
GSK3B P49841 1/20 0.32
USP2 O75604 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4838592 0.81 MEN1 (0.37) IDH2L3MBTL1GAAMAP4K1JAK2
SCHEMBL6016997 0.78 IDH2 (0.43) IDH2L3MBTL1GAAEHMT2CYP3A4
SCHEMBL5555439 0.74 HTR6 (0.33) EHMT2TNIKHTR6SMN1; SMN2MAPK1
SCHEMBL5452111 0.72 GAA (0.36) L3MBTL1GAAEHMT2CYP3A4CYP2D6
SCHEMBL4832352 0.71 IDH2 (0.53) IDH2L3MBTL1GAAEHMT2IRAK4
SCHEMBL4836252 0.69 IDH2 (0.50) IDH2EHMT2SMN1; SMN2MAPTMAPK1
SCHEMBL6607397 0.67 IDH2 (0.53) IDH2EHMT2RAB9AIRAK4
SCHEMBL5037808 0.65 IDH2 (0.43) IDH2EHMT2CYP3A4CYP2D6CYP2C9
SCHEMBL16928568 0.62 IDH2 (0.57) IDH2JAK2RAB9A
SCHEMBL21914609 0.62 ALDH1A1 (0.65) IDH2L3MBTL1GAACYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1436266-A4 METHODS AND COMPOSITIONS OF NOVEL TRIAZINE COMPOUNDS REDDY US THERAPEUTICS INC (US) 2004-12-22 EP claimed
EP-1436266-A2 METHODS AND COMPOSITIONS OF NOVEL TRIAZINE COMPOUNDS Reddy US Therapeutics, Inc. (US) 2004-07-14 EP claimed
WO-2003024926-A2 METHODS AND COMPOSITIONS OF NOVEL TRIAZINE COMPOUNDS REDDY US THERAPEUTICS, INC. (US) 2003-03-27 WO claimed