Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 7/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | GSR | P00390 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6406201 | 0.94 | GSK3B (0.47) | GSK3BPTPN1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL13545219 | 0.84 | SMN1; SMN2 (0.51) | MAPTALDH1A1SMN1; SMN2HSD17B10LMNA | |
| SCHEMBL4345155 | 0.83 | HTT (0.58) | GSK3BMAPTALDH1A1SMN1; SMN2HSD17B10 | |
| Hydrochloric Acid SCHEMBL9863504 | 0.81 | ALDH1A1 (0.49) | MAPTALDH1A1SMN1; SMN2HSD17B10LMNA | |
| SCHEMBL23553765 | 0.80 | MEN1 (0.62) | MAPTALDH1A1SMN1; SMN2HSD17B10LMNA | |
| SCHEMBL30041713 | 0.80 | MEN1 (0.62) | MAPTALDH1A1SMN1; SMN2HSD17B10LMNA | |
| SCHEMBL125350 | 0.79 | GSR (0.59) | GSK3BPTPN1GSR | |
| SCHEMBL11543660 | 0.79 | LMNA (0.48) | MAPTALDH1A1SMN1; SMN2HSD17B10LMNA | |
| SCHEMBL5249012 | 0.79 | SMN1; SMN2 (0.57) | MAPTALDH1A1SMN1; SMN2HSD17B10LMNA | |
| SCHEMBL17290764 | 0.78 | ALDH1A1 (0.50) | MAPTALDH1A1SMN1; SMN2HSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117355300-A | Compounds and their use for the treatment of neurodegenerative, degenerative and metabolic diseases | 佛罗里达大学研究基金会公司 | 2024-01-05 | — | — | CN | disclosed |
| EP-4277623-A1 | COMPOUNDS AND USE THEREOF FOR TREATMENT OF NEURODEGENERATIVE, DEGENERATIVE AND METABOLIC DISORDERS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2023-11-22 | — | — | EP | disclosed |
| WO-2022155463-A1 | COMPOUNDS AND USE THEREOF FOR TREATMENT OF NEURODEGENERATIVE, DEGENERATIVE AND METABOLIC DISORDERS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2022-07-21 | — | — | WO | disclosed |
| WO-2022095989-A1 | P300 INHIBITORS AND USE THEREOF IN MEDICINE | 贝达药业股份有限公司 | 2022-05-12 | — | — | WO | disclosed |
| EP-1289980-B1 | BICYCLYL OR HETEROBICYCLYLMETHANESULFONYLAMINO-SUBSTITUTED N-HYDROXYFORMAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2004-11-17 | — | — | EP | disclosed |
| US-5041567-A | Human and veterianary medicine; veneral diseases respiratory diseases, bovine mastitis | BEECHAM GROUP PLC (GB) | 1991-08-20 | — | — | US | disclosed |
| US-4812470-A | Antibacterial monic acid derivatives | BEECHAM GROUP P.L.C. (GB) | 1989-03-14 | — | — | US | disclosed |
| EP-0087953-B1 | ANTIBACTERIAL 1-NORMON-2-YL-HETEROCYCLIC COMPOUNDS | BEECHAM GROUP PLC (GB) | 1988-04-27 | — | — | EP | disclosed |
| US-4716169-A | INOTROPIC AGENTS | DR. KARL THOMAE GMBH (DE) | 1987-12-29 | — | — | US | disclosed |
| EP-0185345-A1 | Imidazo derivatives, their preparation and medicines containing them | Dr. Karl Thomae GmbH (DE) | 1986-06-25 | — | — | EP | disclosed |
| EP-0185346-A2 | Imidazo derivatives, their preparation and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1986-06-25 | — | — | EP | disclosed |
| EP-0087953-A2 | Antibacterial 1-normon-2-yl-heterocyclic compounds | BEECHAM GROUP PLC (GB) | 1983-09-07 | — | — | EP | disclosed |