Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 16/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CPB1 | P15086 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6607778 | 0.90 | HSD11B1 (0.44) | HSD11B1RAB9AKMT2A | |
| SCHEMBL6626827 | 0.90 | HSD11B1 (0.40) | HSD11B1KMT2A | |
| SCHEMBL6168329 | 0.89 | HSD11B1 (0.37) | HSD11B1 | |
| SCHEMBL28742834 | 0.83 | HSD11B1 (0.34) | HSD11B1 | |
| SCHEMBL6162617 | 0.80 | HSD11B1 (0.36) | HSD11B1 | |
| SCHEMBL6164562 | 0.80 | HSD11B1 (0.39) | HSD11B1 | |
| SCHEMBL6626656 | 0.79 | HSD11B1 (0.52) | HSD11B1 | |
| SCHEMBL6165565 | 0.74 | EP300 (0.33) | HSD11B1KMT2A | |
| SCHEMBL6626793 | 0.74 | EP300 (0.33) | HSD11B1 | |
| SCHEMBL27516904 | 0.74 | HSD11B1 (0.33) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379511-A1 | DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002083652-A1 | DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2002-10-24 | — | — | WO | disclosed |