Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6163606 | 0.85 | HSD11B1 (0.46) | HSD11B1 | |
| SCHEMBL6166266 | 0.85 | TP53 (0.52) | HSD11B1TP53 | |
| SCHEMBL6626827 | 0.77 | HSD11B1 (0.40) | HSD11B1 | |
| SCHEMBL6164562 | 0.73 | HSD11B1 (0.39) | HSD11B1 | |
| SCHEMBL6622656 | 0.71 | HSD11B1 (0.45) | HSD11B1 | |
| SCHEMBL6165700 | 0.70 | HSD11B1 (0.59) | HSD11B1TP53 | |
| SCHEMBL6163897 | 0.69 | HSD11B1 (0.58) | HSD11B1TP53 | |
| SCHEMBL6623169 | 0.69 | NOTUM (0.54) | TP53 | |
| SCHEMBL27515880 | 0.67 | HSD11B1 (0.51) | HSD11B1 | |
| SCHEMBL6607286 | 0.64 | LMNA (0.64) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1268626-C | Dihydro-benzo(b)(1,4)diazepin-2-one derivatives as mglur2 antagonists I | HOFFMANN LA ROCHE (CH) | 2006-08-09 | — | — | CN | disclosed |
| CN-1522252-A | Dihydro-benzo(b)(1,4)diazepin-2-one derivatives as mglur2 antagonists I | - | 2004-08-18 | — | — | CN | disclosed |
| EP-1379511-A1 | DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002083652-A1 | DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2002-10-24 | — | — | WO | disclosed |