Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 15/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6608840 | 0.90 | HSD11B1 (0.42) | HSD11B1RAB9AKMT2A | |
| SCHEMBL6164562 | 0.89 | HSD11B1 (0.39) | HSD11B1MALT1APOBEC3ACASP7CASP6 | |
| SCHEMBL6626827 | 0.88 | HSD11B1 (0.40) | HSD11B1MEN1KMT2AMALT1L3MBTL1 | |
| SCHEMBL28745485 | 0.83 | HSD11B1 (0.36) | HSD11B1MALT1 | |
| SCHEMBL6609350 | 0.82 | HSD11B1 (0.36) | HSD11B1TDP1 | |
| SCHEMBL6168329 | 0.80 | HSD11B1 (0.37) | HSD11B1MALT1 | |
| SCHEMBL6626656 | 0.79 | HSD11B1 (0.52) | HSD11B1 | |
| SCHEMBL6624974 | 0.78 | KAT6A (0.40) | MEN1RAB9AKMT2AAPOBEC3ACASP7 | |
| SCHEMBL6162617 | 0.78 | HSD11B1 (0.36) | HSD11B1MALT1L3MBTL1POLB | |
| SCHEMBL6165821 | 0.74 | HSD11B1 (0.33) | HSD11B1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379511-A1 | DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002083652-A1 | DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2002-10-24 | — | — | WO | disclosed |