SCHEMBL6609007

SCHEMBL6609007

O=C(Cl)c1c(Cl)ccc2ccccc12

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.54
CYP2A6 P11509 4/20 0.52
ABCG2 Q9UNQ0 4/20 0.46
CYP1A2 P05177 3/20 0.45
KMT2A Q03164 3/20 0.44
HSD17B10 Q99714 2/20 0.44
KDM4E B2RXH2 2/20 0.44
MEN1 O00255 2/20 0.44
GLA P06280 1/20 0.44
HPGD P15428 1/20 0.44
CYP2C19 P33261 1/20 0.44
TSHR P16473 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
PAX8 Q06710 1/20 0.42
LMNA P02545 2/20 0.41
MAPT P10636 1/20 0.41
HTT P42858 1/20 0.41
WDR5 P61964 1/20 0.41
ATM Q13315 1/20 0.40
LDHA P00338 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3146455 0.84 HSD17B10 (0.59) ALDH1A1CYP2A6ABCG2CYP1A2KMT2A
SCHEMBL2424747 0.82 NCEH1 (0.51) ALDH1A1CYP2A6ABCG2CYP1A2KMT2A
Hydrochloric Acid SCHEMBL11726958 0.82 KMT2A (0.57) ALDH1A1CYP2A6ABCG2CYP1A2KMT2A
SCHEMBL9521680 0.81 CYP2A6 (0.48) ALDH1A1CYP2A6ABCG2CYP1A2KMT2A
SCHEMBL3697006 0.81 CYP2A6 (0.48) ALDH1A1CYP2A6ABCG2CYP1A2KMT2A
SCHEMBL4958880 0.81 CYP2A6 (0.48) ALDH1A1CYP2A6ABCG2CYP1A2KMT2A
SCHEMBL608187 0.80 WDR5 (0.50) ALDH1A1CYP2A6ABCG2CYP1A2KMT2A
SCHEMBL29819980 0.80 WDR5 (0.50) ALDH1A1CYP2A6ABCG2CYP1A2KMT2A
SCHEMBL3918323 0.80 ABCG2 (0.54) ALDH1A1ABCG2CYP1A2KMT2AHSD17B10
SCHEMBL1925120 0.78 ALDH1A1 (0.44) ALDH1A1CYP2A6ABCG2CYP1A2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1119551-B1 NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS ASTRAZENECA AB (SE) 2004-12-29 EP disclosed
EP-1433783-A2 Naphthalenecarboxamides as tachykinin receptor antagonists AstraZeneca AB (SE) 2004-06-30 EP disclosed
CN-1322196-A Naphthalenecarboxamides as tachykinin receptor antagonists ASTRA ZENECA N N (SE) 2001-11-14 CN disclosed
EP-1119551-A1 NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS AstraZeneca AB (SE) 2001-08-01 EP disclosed
WO-2000020389-A1 NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS ASTRAZENECA AB (SE) 2000-04-13 WO disclosed
US-4122116-A HERBICIDES DEUTSCHE GOLD- UND SILBER- SCHEIDEANSTALT VORMALS ROESSLER (DE) 1978-10-24 US disclosed
US-4108877-A REACTING ACYL HALIDE WITH COPPER CYANIDE WITH HEATING IN THE PRESENCE OF A CARBOXYLIC ACID NITRILE AND AN ORGANIC SOLVENT DEUTSCHE GOLD- UND SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DE) 1978-08-22 US disclosed
US-4108875-A REACTING ACYL HALIDE WITH AN ALKALI METAL CYANIDE AND A COPPER(I) SALT IN THE PRESENCE OF A CARBOXYLIC ACID NITRILE WITH HEATING DEUTSCHE GOLD- UND SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DE) 1978-08-22 US disclosed
US-4018767-A 5-ENDO-(1-NAPHTHOYLOXY)-N-(AMINOALKYL) BICYCLO(2.2.1)HEPTANE-2,3-DI-ENDO-CARBOXYLIC ACID IMIDES BRISTOL-MYERS COMPANY (US) 1977-04-19 US disclosed