Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA3 | P07451 | 2/20 | 0.46 |
| ▸ | CA4 | P22748 | 2/20 | 0.46 |
| ▸ | CA6 | P23280 | 2/20 | 0.46 |
| ▸ | CA5A | P35218 | 2/20 | 0.46 |
| ▸ | CA7 | P43166 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3736397 | 0.81 | PTGS2 (0.52) | PTGS2 | |
| SCHEMBL8594103 | 0.77 | CA2 (0.57) | CA12CA1CA2CA3CA4 | |
| SCHEMBL3906959 | 0.76 | NR3C2 (0.61) | SMN1; SMN2GAANR3C2CA12CA1 | |
| SCHEMBL8080277 | 0.75 | SMN1; SMN2 (0.70) | SMN1; SMN2GAANR3C2CA12CA1 | |
| SCHEMBL6608198 | 0.73 | KEAP1 (0.53) | SMN1; SMN2NR3C2CA12CA1CA2 | |
| SCHEMBL7179095 | 0.73 | FEN1 (0.41) | NR3C2L3MBTL1LMNAALDH1A1POLB | |
| SCHEMBL9694039 | 0.73 | NPC1 (0.44) | SMN1; SMN2CA12CA1CA2CA9 | |
| SCHEMBL15015953 | 0.73 | TNNI3K (0.43) | SMN1; SMN2GAACA12CA1CA2 | |
| SCHEMBL16719761 | 0.73 | SMN1; SMN2 (0.43) | SMN1; SMN2GAANR3C2CA12CA1 | |
| SCHEMBL7629070 | 0.73 | SMN1; SMN2 (0.80) | SMN1; SMN2GAANR3C2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1423386-A1 | THIOPHENYLTHIOPYRANE DIOXIDES AS MMP OR TNF-ALPHA INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-06-02 | — | — | EP | claimed |
| WO-2003022842-A1 | THIOPHENYLTHIOPYRANE DIOXIDES AS MMP OR TNF-ALPHA INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-03-20 | — | — | WO | claimed |