Sugi Predict

Sugi Predict / Compounds / SCHEMBL6609166

SCHEMBL6609166

SCHEMBL6609166

O=C(O)C=CN1CCCC1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 2/20 0.42
▸ TP53 P04637 1/20 0.42
▸ EGLN1 Q9GZT9 1/20 0.42
▸ EGLN3 Q9H6Z9 1/20 0.42
▸ INMT O95050 4/20 0.38
▸ BLM P54132 1/20 0.37
▸ ALDH1A1 P00352 5/20 0.36
▸ MAPT P10636 3/20 0.36
▸ NPC1 O15118 2/20 0.36
▸ USP2 O75604 2/20 0.36
▸ MAPK1 P28482 2/20 0.36
▸ LMNA P02545 1/20 0.36
▸ THRB P10828 1/20 0.35
▸ HPGD P15428 2/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ POLB P06746 1/20 0.34
▸ HSP90AA1 P07900 1/20 0.34
▸ ALOX12 P18054 1/20 0.34
▸ RAB9A P51151 1/20 0.34
▸ KMT2A Q03164 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6609163 1.00 TSHR (0.42) TSHRTP53EGLN1EGLN3INMT
SCHEMBL4125262 0.97 TSHR (0.40) TSHRTP53EGLN1EGLN3INMT
SCHEMBL4125267 0.97 TSHR (0.40) TSHRTP53EGLN1EGLN3INMT
SCHEMBL9678617 0.80 HSD17B10 (0.41) TSHRTP53EGLN1EGLN3ALDH1A1
SCHEMBL28716123 0.80 RAB9A (0.53) TP53ALDH1A1MAPTNPC1USP2
SCHEMBL28094529 0.76 ALDH1A1 (0.39) ALDH1A1MAPTNPC1USP2MAPK1
SCHEMBL18195434 0.76 ALDH1A1 (0.39) ALDH1A1MAPTNPC1USP2MAPK1
SCHEMBL30166170 0.76 NPC1 (0.39) TSHRTP53ALDH1A1MAPTNPC1
Fumaric Acid SCHEMBL4771229 0.74 TSHR (0.53) TSHRTP53EGLN1EGLN3INMT
Maleic Acid SCHEMBL31167986 0.74 TSHR (0.53) TSHRTP53EGLN1EGLN3INMT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12024524-B2 Imidazopyridazines as modulators of IL-17 JANSSEN PHARMACEUTICA NV (BE) 2024-07-02 — — US disclosed
US-20230357254-A1 IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 JANSSEN PHARMACEUTICA NV (BE) 2023-11-09 — — US disclosed
US-11702422-B2 Imidazopyridazines as modulators of IL-17 JANSSEN PHARMACEUTICA NV (BE) 2023-07-18 — — US disclosed
US-11691979-B2 Imidazopyridazines as modulators of IL-17 JANSSEN PHARMACEUTICA NV (BE) 2023-07-04 — — US disclosed
US-20230081548-A1 IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 JANSSEN PHARMACEUTICA NV (BE) 2023-03-16 — — US disclosed
US-20220402922-A1 IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 JANSSEN RESEARCH & DEVELOPMENT, LLC 2022-12-22 — — US disclosed
US-11034698-B2 Pyrazolo[ 1,5a]pyrimidine derivatives as IRAK4 modulators GENENTECH, INC. (US) 2021-06-15 — — US disclosed
EP-3642204-A1 PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS H. Hoffnabb-La Roche Ag (CH) 2020-04-29 — — EP disclosed
US-20200123166-A1 PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS GENENTECH, INC. (US) 2020-04-23 — — US disclosed
WO-2018234345-A1 PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS F. HOFFMANN-LA ROCHE AG (CH) 2018-12-27 — — WO disclosed
CN-102271515-B Pyrazolopyrimidine jak inhibitor compounds and methods GENENTECH INC 2014-07-02 — — CN disclosed
CN-102271515-A Pyrazolopyrimidine JAK inhibitor compounds and methods — 2011-12-07 — — CN disclosed
EP-1379511-A1 DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II F. HOFFMANN-LA ROCHE AG (CH) 2004-01-14 — — EP disclosed
WO-2002083652-A1 DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II F. HOFFMANN-LA ROCHE AG (CH) 2002-10-24 — — WO disclosed
US-4261728-A PREEMERGENT ACTIVITY MONSANTO COMPANY (US) 1981-04-14 — — US disclosed
US-4187099-A 3-Aryl-4-isothiazolecarboxylic acid and 3-aryl-4-isoxazolecarboxylic acid derivatives and their use as herbicides MONSANTO COMPANY (US) 1980-02-05 — — US disclosed
US-4144047-A SOYBEANS MONSANTO COMPANY (US) 1979-03-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11691979-B2 Imidazopyridazines as modulators of IL-17 IL17A, IL23R, IL15 TSHR 481/4885TP53 1513/4885EGLN1 1665/4885
US-20230357254-A1 IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 IL17A, IL23R, IL15 TSHR 481/4885TP53 1513/4885EGLN1 1665/4885
US-11034698-B2 Pyrazolo[ 1,5a]pyrimidine derivatives as IRAK4 modulators IRAK4, IRAK1, IRAK2 TSHR 3222/4885TP53 2250/4885EGLN1 1676/4885
US-12024524-B2 Imidazopyridazines as modulators of IL-17 IL17A, IL23R, IL15 TSHR 481/4885TP53 1513/4885EGLN1 1665/4885
US-20230081548-A1 IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 IL17A, IL23R, IL15 TSHR 481/4885TP53 1513/4885EGLN1 1665/4885
US-20220402922-A1 IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 IL17A, IL23R, IL15 TSHR 481/4885TP53 1513/4885EGLN1 1665/4885
US-11702422-B2 Imidazopyridazines as modulators of IL-17 IL17A, IL23R, IL15 TSHR 481/4885TP53 1513/4885EGLN1 1665/4885
US-20200123166-A1 PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS IRAK4, IRAK1, IRAK2 TSHR 3222/4885TP53 2250/4885EGLN1 1676/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.