Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.53 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.53 |
| ▸ | INMT | O95050 | 6/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL4771239 | 1.00 | TSHR (0.53) | TSHRTP53EGLN1EGLN3INMT | |
| Maleic Acid SCHEMBL31167986 | 1.00 | TSHR (0.53) | TSHRTP53EGLN1EGLN3INMT | |
| Maleic Acid SCHEMBL27727045 | 0.78 | TSHR (0.47) | TSHRTP53EGLN1EGLN3INMT | |
| Fumaric Acid SCHEMBL18586002 | 0.77 | TSHR (0.75) | TSHRTP53EGLN1EGLN3INMT | |
| Maleic Acid SCHEMBL10749964 | 0.77 | TSHR (0.75) | TSHRTP53EGLN1EGLN3INMT | |
| Maleic Acid SCHEMBL27628514 | 0.77 | TSHR (0.53) | TSHRTP53EGLN1EGLN3INMT | |
| SCHEMBL12172750 | 0.76 | ALDH1A1 (0.49) | TSHRTP53EGLN1EGLN3INMT | |
| Carbamic Acid SCHEMBL2830897 | 0.75 | ACHE (0.47) | ALDH1A1NPC1SMN1; SMN2 | |
| Fumaric Acid SCHEMBL4386695 | 0.74 | TSHR (0.69) | TSHRTP53EGLN1EGLN3INMT | |
| Maleic Acid SCHEMBL10401872 | 0.74 | TSHR (0.69) | TSHRTP53EGLN1EGLN3INMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101426778-A | N-substituted-azacyclylamines as histamine-3 antagonists | WYETH CORP (US) | 2009-05-06 | — | — | CN | disclosed |
| EP-1994022-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007108936-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2007-09-27 | — | — | WO | disclosed |