Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 16/20 | 0.53 |
| ▸ | ESR1 | P03372 | 6/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL432492 | 1.00 | ESR2 (0.53) | ESR2ESR1CYP3A4CYP2C9HDAC2 | |
| SCHEMBL14379229 | 0.86 | KCNH2 (0.48) | DGAT1 | |
| SCHEMBL20838768 | 0.86 | KCNH2 (0.48) | DGAT1 | |
| SCHEMBL17025330 | 0.86 | KCNH2 (0.48) | DGAT1 | |
| SCHEMBL14379232 | 0.86 | KCNH2 (0.48) | DGAT1 | |
| SCHEMBL22102107 | 0.85 | DGAT1 (0.42) | CYP2C9DGAT1CYP2D6 | |
| SCHEMBL3539868 | 0.85 | DGAT1 (0.42) | ESR2CYP2C9DGAT1 | |
| SCHEMBL5032260 | 0.80 | ESR2 (0.62) | ESR2ESR1CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL13009628 | 0.80 | ESR2 (0.54) | ESR2ESR1CYP3A4CYP2C9HDAC2 | |
| SCHEMBL27709005 | 0.80 | ESR2 (0.54) | ESR2ESR1CYP3A4CYP2C9HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2423182-A1 | DIACYLETHYLENEDIAMINE COMPOUND | Astellas Pharma Inc. (JP) | 2012-02-29 | — | — | EP | disclosed |
| US-20120046292-A1 | DIACYLETHYLENEDIAMINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046292-A1 | DIACYLETHYLENEDIAMINE COMPOUND | DGAT1, DGAT2, DIMT1 | ESR2 3697/4885ESR1 4281/4885CYP3A4 3870/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.