Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6608333 | 0.82 | CGAS (0.40) | TRPV1LMNA | |
| SCHEMBL5880978 | 0.78 | KMT2A (0.52) | LMNAMAPT | |
| SCHEMBL5881013 | 0.75 | TACR1 (0.40) | ACHEBCHETACR1SIGMAR1LMNA | |
| SCHEMBL5880987 | 0.75 | TACR1 (0.40) | ACHEBCHETACR1SIGMAR1LMNA | |
| SCHEMBL4969326 | 0.75 | MAPT (0.43) | TACR1TRPV1TAAR1LMNAMAPT | |
| SCHEMBL5880983 | 0.74 | ACHE (0.38) | ACHEBCHETACR1SIGMAR1GRIN2B | |
| SCHEMBL5880988 | 0.74 | ACHE (0.38) | ACHEBCHETACR1SIGMAR1LMNA | |
| SCHEMBL5880926 | 0.72 | TACR1 (0.38) | ACHEBCHETACR1SIGMAR1GRIN2B | |
| SCHEMBL11838605 | 0.72 | LMNA (0.47) | TACR1TRPV1TAAR1LMNAMAPT | |
| SCHEMBL5880984 | 0.70 | ACHE (0.40) | ACHEBCHETACR1SIGMAR1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453803-A2 | TETRAHYDROCARBOZOLE DERIVATIVES AS LIGANDS FOR G-PROTEIN COUPLED RECEPTORS (GPCR) | Zentaris GmbH (DE) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003051837-A2 | TETRAHYDROCARBOZOLE DERIVATIVES AS LIGANDS FOR G-PROTEIN COUPLED RECEPTORS (GPCR) | ZENTARIS GMBH (DE) | 2003-06-26 | — | — | WO | disclosed |