Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 2/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.42 |
| ▸ | NR2E1 | Q9Y466 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HTR5A | P47898 | 1/20 | 0.41 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6526481 | 0.81 | LMNA (0.45) | MAPTLMNABAZ2BHTR2AHTR2C | |
| SCHEMBL1114261 | 0.81 | LMNA (0.45) | MAPTLMNABAZ2BHTR2AHTR2C | |
| SCHEMBL6610802 | 0.81 | BAZ2B (0.52) | LMNABAZ2BSIRT1CYP1A2CYP2D6 | |
| SCHEMBL6645281 | 0.80 | MAPKAPK2 (0.52) | MAPTLMNAKDM4EALDH1A1CYP1A2 | |
| SCHEMBL11838605 | 0.78 | LMNA (0.47) | MAPTLMNABAZ2BHTR2AHTR2C | |
| SCHEMBL6609382 | 0.77 | TACR1 (0.51) | MAPTLMNABAZ2BHTR2AHTR2C | |
| SCHEMBL31684725 | 0.75 | HTR2A (0.46) | HTR2AHTR2CNR2E1KDM4EHTR5A | |
| SCHEMBL6609995 | 0.75 | ACHE (0.43) | MAPTLMNABAZ2BTRPV1TACR1 | |
| SCHEMBL6612080 | 0.75 | TACR1 (0.43) | MAPTLMNABAZ2BKDM4ETACR1 | |
| SCHEMBL11204300 | 0.75 | HTR2A (0.47) | MAPTLMNABAZ2BHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1995238-A2 | Novel tetrahydrocarbazole derivatives with improved biological action and improved solubility as ligands for g-protein coupled receptors (GPCRS) | AEterna Zentaris GmbH (DE) | 2008-11-26 | — | — | EP | disclosed |
| EP-1765776-B1 | NOVEL TETRAHYDROCARBAZOLE DERIVATIVES WITH IMPROVED BIOLOGICAL ACTION AND IMPROVED SOLUBILITY AS LIGANDS FOR G-PROTEIN COUPLED RECEPTORS (GPCRS) | AETERNA ZENTARIS GMBH (DE) | 2008-08-27 | — | — | EP | disclosed |
| EP-1765776-A1 | NOVEL TETRAHYDROCARBAZOLE DERIVATIVES WITH IMPROVED BIOLOGICAL ACTION AND IMPROVED SOLUBILITY AS LIGANDS FOR G-PROTEIN COUPLED RECEPTORS (GPCRS) | Zentaris GmbH (DE) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006005484-A1 | NOVEL TETRAHYDROCARBAZOLE DERIVATIVES WITH IMPROVED BIOLOGICAL ACTION AND IMPROVED SOLUBILITY AS LIGANDS FOR G-PROTEIN COUPLED RECEPTORS (GPCRS) | ZENTARIS GMBH (DE) | 2006-01-19 | — | — | WO | disclosed |
| EP-1453803-A2 | TETRAHYDROCARBOZOLE DERIVATIVES AS LIGANDS FOR G-PROTEIN COUPLED RECEPTORS (GPCR) | Zentaris GmbH (DE) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003051837-A2 | TETRAHYDROCARBOZOLE DERIVATIVES AS LIGANDS FOR G-PROTEIN COUPLED RECEPTORS (GPCR) | ZENTARIS GMBH (DE) | 2003-06-26 | — | — | WO | disclosed |