Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | ESR1 | P03372 | 2/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6609980 | 0.86 | SIGMAR1 (0.53) | ADRA1DADRA1AADRA1BLMNAESR1 | |
| SCHEMBL6609979 | 0.86 | SIGMAR1 (0.53) | ADRA1DADRA1AADRA1BLMNAESR1 | |
| SCHEMBL7154434 | 0.86 | LMNA (0.59) | ADRA1DADRA1AADRA1BLMNAESR1 | |
| SCHEMBL7154439 | 0.86 | LMNA (0.59) | ADRA1DADRA1AADRA1BLMNAESR1 | |
| SCHEMBL6951397 | 0.77 | ABCG2 (0.48) | KDM4EALDH1A1ADRA1DADRA1AADRA1B | |
| SCHEMBL7492514 | 0.77 | PDE5A (0.55) | — | |
| SCHEMBL6599818 | 0.76 | ABCB1 (0.46) | ADRA1DADRA1AADRA1BLMNAABCG2 | |
| SCHEMBL6615462 | 0.73 | PDE5A (0.54) | — | |
| SCHEMBL7497181 | 0.72 | ABCG2 (0.62) | ALDH1A1LMNAABCG2ABCB1MAPT | |
| SCHEMBL23875966 | 0.71 | KIF11 (0.63) | GAAKDM4ELMNAESR1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458679-A2 | PYRROLIDINE DERIVATIVES AS PROSTAGLANDIN MODULATORS | Applied Research Systems ARS Holding N.V. (AN) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003053923-A2 | PYRROLIDINE DERIVATIVES AS PROSTAGLANDIN MODULATORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2003-07-03 | — | — | WO | disclosed |