Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6609911 | 0.88 | MAPT (0.43) | SMN1; SMN2MAPTALDH1A1TP53BCHE | |
| SCHEMBL6608759 | 0.88 | MAPT (0.43) | MEN1KMT2ARAB9ASMN1; SMN2MAPT | |
| SCHEMBL6611162 | 0.86 | BCHE (0.39) | MEN1KMT2ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL6610439 | 0.86 | MAPT (0.45) | MEN1KMT2APOLBRAB9ASMN1; SMN2 | |
| SCHEMBL6611416 | 0.85 | ALDH1A1 (0.40) | MEN1KMT2APOLBRAB9ASMN1; SMN2 | |
| SCHEMBL6616178 | 0.85 | SMN1; SMN2 (0.47) | MEN1KMT2APOLBSMN1; SMN2MAPT | |
| SCHEMBL6610923 | 0.85 | HSD17B10 (0.42) | MEN1KMT2ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL6611117 | 0.84 | MAPT (0.41) | SMN1; SMN2MAPTALDH1A1MCL1TP53 | |
| SCHEMBL5843128 | 0.84 | MAPT (0.58) | RAB9ASMN1; SMN2MAPTALDH1A1NPC1 | |
| SCHEMBL6611013 | 0.84 | MAPT (0.39) | MEN1KMT2APOLBSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463724-A1 | PYRROLIDONE CARBOXAMIDES | Actelion Pharmaceuticals Ltd. (CH) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003059905-A1 | PYRROLIDONE CARBOXAMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2003-07-24 | — | — | WO | disclosed |