Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6615605 | 0.92 | MGLL (0.52) | MAPTFAAHMGLLALDH1A1TP53 | |
| SCHEMBL6608759 | 0.92 | MAPT (0.43) | MAPTHSD17B10ALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL6610439 | 0.90 | MAPT (0.45) | MAPTALDH1A1SMN1; SMN2LMNATP53 | |
| SCHEMBL6610923 | 0.89 | HSD17B10 (0.42) | MAPTHSD17B10ALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL6616178 | 0.89 | SMN1; SMN2 (0.47) | MAPTHSD17B10ALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL6611117 | 0.89 | MAPT (0.41) | MAPTHSD17B10ALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL6610069 | 0.88 | MEN1 (0.43) | MAPTALDH1A1SMN1; SMN2LMNATP53 | |
| SCHEMBL6614360 | 0.87 | MEN1 (0.41) | MAPTHSD17B10ALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL6615199 | 0.87 | MAPK1 (0.47) | MAPTHSD17B10ALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL6609668 | 0.86 | MAPT (0.40) | MAPTALDH1A1SMN1; SMN2NPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463724-A1 | PYRROLIDONE CARBOXAMIDES | Actelion Pharmaceuticals Ltd. (CH) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003059905-A1 | PYRROLIDONE CARBOXAMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2003-07-24 | — | — | WO | disclosed |