Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6614360 | 0.92 | MEN1 (0.41) | SMN1; SMN2MAPTMEN1KMT2ALMNA | |
| SCHEMBL6610923 | 0.92 | HSD17B10 (0.42) | SMN1; SMN2MAPTMEN1KMT2ALMNA | |
| SCHEMBL6615199 | 0.90 | MAPK1 (0.47) | SMN1; SMN2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL6609911 | 0.89 | MAPT (0.43) | SMN1; SMN2MAPTLMNAALDH1A1NPSR1 | |
| SCHEMBL6611273 | 0.89 | MAPT (0.48) | SMN1; SMN2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL6608607 | 0.89 | HSD17B10 (0.40) | SMN1; SMN2MAPTMEN1KMT2ALMNA | |
| SCHEMBL6614799 | 0.89 | MAPT (0.50) | SMN1; SMN2MAPTMEN1KMT2ALMNA | |
| SCHEMBL6608759 | 0.89 | MAPT (0.43) | SMN1; SMN2MAPTMEN1KMT2ALMNA | |
| SCHEMBL6609572 | 0.88 | NPC1 (0.46) | SMN1; SMN2MAPTMEN1KMT2ALMNA | |
| SCHEMBL6613107 | 0.87 | MAPT (0.44) | SMN1; SMN2MAPTLMNATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463724-A1 | PYRROLIDONE CARBOXAMIDES | Actelion Pharmaceuticals Ltd. (CH) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003059905-A1 | PYRROLIDONE CARBOXAMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2003-07-24 | — | — | WO | disclosed |