Sugi Predict

Sugi Predict / Compounds / SCHEMBL66108

SCHEMBL66108

SCHEMBL66108

CC(C)(C)c1ccc(S(=O)(=O)Cl)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 10/20 0.61
▸ HSD11B1 P28845 1/20 0.53
▸ HTT P42858 3/20 0.49
▸ NPSR1 Q6W5P4 2/20 0.49
▸ USP2 O75604 1/20 0.49
▸ ALOX15 P16050 1/20 0.49
▸ LMNA P02545 2/20 0.48
▸ GAA P10253 1/20 0.48
▸ TDP1 Q9NUW8 3/20 0.48
▸ HSD17B10 Q99714 2/20 0.48
▸ HPGD P15428 3/20 0.47
▸ MEN1 O00255 3/20 0.47
▸ KMT2A Q03164 3/20 0.47
▸ SMN1; SMN2 Q16637 3/20 0.47
▸ TSHR P16473 2/20 0.47
▸ MAPT P10636 3/20 0.47
▸ KDM4E B2RXH2 2/20 0.47
▸ CYP1A2 P05177 2/20 0.47
▸ CYP3A4 P08684 2/20 0.47
▸ CYP2C19 P33261 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17897408 0.94 ALDH1A1 (0.55) ALDH1A1HSD11B1HTTNPSR1USP2
SCHEMBL14533597 0.88 ALDH1A1 (0.50) ALDH1A1HSD11B1HTTNPSR1USP2
SCHEMBL3041567 0.86 ALDH1A1 (0.48) ALDH1A1HSD11B1HTTLMNAGAA
SCHEMBL3227670 0.85 ALDH1A1 (0.45) ALDH1A1HSD11B1HTTNPSR1USP2
SCHEMBL27685431 0.84 ALDH1A1 (0.46) ALDH1A1HSD11B1HTTNPSR1USP2
SCHEMBL3976090 0.82 ALDH1A1 (0.44) ALDH1A1HSD11B1HTTNPSR1USP2
SCHEMBL13220215 0.82 ALDH1A1 (0.57) ALDH1A1HSD11B1HTTNPSR1USP2
SCHEMBL31190709 0.82 ALDH1A1 (0.44) ALDH1A1HSD11B1TDP1HSD17B10
SCHEMBL13430569 0.82 ALDH1A1 (0.44) ALDH1A1HSD11B1HTTNPSR1USP2
SCHEMBL1085985 0.82 HSD11B1 (0.56) ALDH1A1HSD11B1TDP1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1570 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4692062-A1 NOVEL AMIDE-BASED COMPOUND AND COMPOSITION COMPRISING SAME Amorepacific Corporation (KR) 2026-02-11 — — EP claimed
US-12258343-B2 Method for preparing 2-[(3R)-3-methylmorpholin-4-yl]-4-[1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridine BAYER AKTIENGESELLSCHAFT (DE) 2025-03-25 — — US claimed
CN-118580140-B Twelve-alkynyl nonionic Gemini surfactant with low surface tension and low foamability and preparation method thereof 杭州格林达电子材料股份有限公司 2025-02-18 — — CN claimed
CN-119425423-A Positively charged composite membrane and preparation method and application thereof 中国石油化工股份有限公司 2025-02-14 — — CN claimed
WO-2024205303-A1 NOVEL AMIDE-BASED COMPOUND AND COMPOSITION COMPRISING SAME (주)아모레퍼시픽 2024-10-03 — — WO claimed
CN-117776955-A Synthetic method of mugwort Fu Nibu and intermediate thereof 苏州莱安医药化学技术有限公司 2024-03-29 — — CN claimed
CN-117510566-A Method for preparing alfasin 湖南唯美胜科技有限公司 2024-02-06 — — CN claimed
CN-116120261-B Preparation method of 3- [ (4-sulfadiazine-1-yl) methyl ] benzoic acid compound 浙大宁波理工学院 2024-01-23 — — CN claimed
CN-112823158-B Process for preparing 2- [ (3R) -3-methylmorpholin-4-yl ] -4- (1-methyl-1H-pyrazol-5-yl) -8- (1H-pyrazol-5-yl) -1, 7-naphthyridine 拜耳股份有限公司 2023-08-15 — — CN claimed
CN-116120261-A Preparation method of 3- [ (4-sulfadiazine-1-yl) methyl ] benzoic acid compound 浙大宁波理工学院 2023-05-16 — — CN claimed
US-20210253573-A1 METHOD FOR PREPARING 2-[(3R)-3-METHYLMORPHOLIN-4-YL]-4-[1-METHYL-1H-PYRAZOL-5-YL)-8-(1H-PYRAZOL-5-YL)-1,7-NAPHTHYRIDINE BAYER AKTIENGESELLSCHAFT (DE) 2021-08-19 — — US claimed
CN-109180478-B Diphenheptane compounds, preparation method and application thereof 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） 2021-07-20 — — CN claimed
CN-112823158-A Process for the preparation of 2- [ (3R) -3-methylmorpholin-4-yl ] -4- (1-methyl-1H-pyrazol-5-yl) -8- (1H-pyrazol-5-yl) -1, 7-naphthyridine 拜耳股份有限公司 2021-05-18 — — CN claimed
CN-111574413-A Preparation method of sulfonylamidine using 2-aminomethyl pyridine and DMF-DMA as amine source 杭州尚合生物医药科技有限公司 2020-08-25 — — CN claimed
CN-108191746-B Hydroxypyridones compound and preparation method and application thereof 暨南大学 2020-06-16 — — CN claimed
CN-108440389-B 3,4, 5-trihydroxybenzoic acid derivative and preparation method and application thereof 山东大学 2020-05-29 — — CN claimed
CN-110218193-A 3- hydroxyquinazoline -2,4 (1H, 3H)-diketone derivative and the preparation method and application thereof 山东大学 2019-09-10 — — CN claimed
CN-104678028-A Pretreatment and detection method for biogen amine neurotransmitter and detection kit INST PHARM & TOXICOLOGY AMMS 2015-06-03 — — CN claimed
EP-1377589-B1 OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS PHARMACIA ITALIA SPA (IT) 2005-09-07 — — EP claimed
US-5120457-A Wear and oxidation resistance MOBIL OIL CORP. (US) 1992-06-09 — — US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12258343-B2 Method for preparing 2-[(3R)-3-methylmorpholin-4-yl]-4-[1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridine CYP1B1, CYP4B1, CYP1A1 ALDH1A1 432/4885HSD11B1 272/4885HTT 3183/4885
US-20210253573-A1 METHOD FOR PREPARING 2-[(3R)-3-METHYLMORPHOLIN-4-YL]-4-[1-METHYL-1H-PYRAZOL-5-YL)-8-(1H-PYRAZOL-5-YL)-1,7-NAPHTHYRIDINE CYP1B1, CYP4B1, CYP1A1 ALDH1A1 432/4885HSD11B1 272/4885HTT 3183/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.