Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3041567 | 0.82 | ALDH1A1 (0.48) | ALDH1A1TDP1HSD17B10HSD11B1NR3C2 | |
| SCHEMBL66108 | 0.82 | ALDH1A1 (0.61) | ALDH1A1TDP1HSD17B10HSD11B1HTT | |
| SCHEMBL27685431 | 0.80 | ALDH1A1 (0.46) | ALDH1A1TDP1HSD17B10HSD11B1NR3C2 | |
| SCHEMBL13430564 | 0.78 | CA2 (0.52) | TDP1NPSR1USP2MEN1TSHR | |
| SCHEMBL1085985 | 0.78 | HSD11B1 (0.56) | ALDH1A1TDP1HSD17B10HSD11B1 | |
| SCHEMBL31190709 | 0.78 | ALDH1A1 (0.44) | ALDH1A1TDP1HSD17B10HSD11B1 | |
| SCHEMBL17897408 | 0.77 | ALDH1A1 (0.55) | ALDH1A1TDP1HSD17B10HSD11B1HTT | |
| SCHEMBL651902 | 0.75 | ALDH1A1 (0.71) | ALDH1A1TDP1HSD17B10USP2LMNA | |
| SCHEMBL344370 | 0.75 | NPC1 (0.43) | ALDH1A1TDP1HSD17B10HSD11B1LMNA | |
| SCHEMBL28726319 | 0.75 | ALDH1A1 (0.41) | ALDH1A1TDP1HSD17B10HSD11B1NR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8080549-B2 | Endothelin receptor antagonists | CONCERT PHARMACEUTICALS, INC. (US) | 2011-12-20 | — | — | US | disclosed |
| US-8071596-B2 | Endothelin receptor antagonists | CONCERT PHARMACEUTICALS, INC. (US) | 2011-12-06 | — | — | US | disclosed |
| US-20100063076-A1 | Endothelin receptor antagonists | SUN PHARMACEUTICAL INDUSTRIES, INC. | 2010-03-11 | — | — | US | disclosed |
| US-20090005394-A1 | Endothelin receptor antagonists | SUN PHARMACEUTICAL INDUSTRIES, INC. | 2009-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063076-A1 | Endothelin receptor antagonists | EDNRA, EDNRB, ECE1 | ALDH1A1 3474/4885TDP1 2153/4885HSD17B10 2449/4885 |
| US-20090005394-A1 | Endothelin receptor antagonists | EDNRA, EDNRB, ECE1 | ALDH1A1 3953/4885TDP1 1468/4885HSD17B10 2391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.