Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 5/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | MMP1 | P03956 | 3/20 | 0.41 |
| ▸ | MMP2 | P08253 | 3/20 | 0.41 |
| ▸ | MMP9 | P14780 | 3/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.41 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.41 |
| ▸ | PELI1 | Q96FA3 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.38 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.38 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.38 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6611347 | 1.00 | MTNR1A (0.43) | MTNR1AMTNR1BEGFRMAOBMMP1 | |
| SCHEMBL16370394 | 0.83 | LPAR2 (0.62) | LPAR1LPAR2CREBBPKDM4EPARP1 | |
| SCHEMBL16370465 | 0.83 | LPAR2 (0.62) | LPAR1LPAR2CREBBPKDM4EPARP1 | |
| SCHEMBL28085497 | 0.83 | BTK (0.41) | EGFRMAOBMMP1MMP2MMP9 | |
| SCHEMBL995472 | 0.79 | TGM2 (0.61) | EGFRLMNATGM2 | |
| SCHEMBL22660301 | 0.79 | AKT1 (0.43) | EGFRMAOBMMP1MMP2MMP9 | |
| SCHEMBL22660285 | 0.79 | EGFR (0.44) | EGFRERBB2 | |
| SCHEMBL25365033 | 0.79 | MTNR1A (0.47) | MTNR1AMTNR1BEGFRMAOBMMP1 | |
| SCHEMBL4147796 | 0.78 | MMP1 (0.63) | MTNR1AMTNR1BEGFRMAOBMMP1 | |
| SCHEMBL4147799 | 0.78 | MMP1 (0.63) | MTNR1AMTNR1BEGFRMAOBMMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140895-B1 | THIOPYRAN COMPOUNDS AS INHIBITORS OF MMP | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-03-24 | — | — | EP | claimed |
| EP-1140895-B1 | THIOPYRAN COMPOUNDS AS INHIBITORS OF MMP | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-03-24 | — | — | EP | disclosed |