Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7140862 | 0.89 | KCNJ11 (0.55) | KCNJ11MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL7742482 | 0.85 | MEN1 (0.52) | KCNJ11MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL6611475 | 0.84 | KCNJ11 (0.43) | KCNJ11MEN1KMT2ACYP1A2CYP2C19 | |
| SCHEMBL7736656 | 0.84 | POLB (0.43) | KCNJ11MEN1KMT2ACYP1A2CYP2C19 | |
| SCHEMBL6611989 | 0.84 | SLC6A9 (0.41) | KCNJ11MEN1KMT2ACYP1A2CYP2C19 | |
| SCHEMBL6612989 | 0.82 | RXFP1 (0.52) | MEN1KMT2ACYP2C19SMN1; SMN2HTT | |
| SCHEMBL6613974 | 0.80 | NPC1 (0.39) | KCNJ11CYP1A2CYP2C19HTTMAPT | |
| SCHEMBL6612032 | 0.80 | KMT2A (0.49) | MEN1KMT2ACYP2C19SMN1; SMN2HTT | |
| SCHEMBL6612097 | 0.80 | MEN1 (0.55) | MEN1KMT2ACYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL4680296 | 0.80 | KCNJ11 (0.48) | KCNJ11POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003506355-A | — | — | 2003-02-18 | — | — | JP | claimed |
| EP-1198456-A2 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2002-04-24 | — | — | EP | claimed |
| WO-2001009096-A2 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2001-02-08 | — | — | WO | claimed |
| EP-1392655-A2 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002062762-A2 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | disclosed |