Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RAPGEF3 | O95398 | 2/20 | 0.40 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.40 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.39 |
| ▸ | KCNJ11 | Q14654 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7742482 | 0.91 | MEN1 (0.52) | MEN1KMT2AKCNJ11LMNAMAPT | |
| SCHEMBL6611475 | 0.86 | KCNJ11 (0.43) | MEN1KMT2AKCNJ11CYP1A2CYP2C19 | |
| SCHEMBL7736656 | 0.86 | POLB (0.43) | MEN1KMT2ARAPGEF3RAPGEF4KCNJ11 | |
| SCHEMBL6641043 | 0.84 | KCNJ11 (0.47) | KCNJ11CYP2C9ABCC9ABCC8KCNJ8 | |
| SCHEMBL6611355 | 0.84 | KCNJ11 (0.42) | MEN1KMT2AKCNJ11CYP1A2CYP2C19 | |
| SCHEMBL7145794 | 0.84 | KCNJ11 (0.44) | KCNJ11ABCC9ABCC8KCNJ8 | |
| SCHEMBL6612989 | 0.84 | RXFP1 (0.52) | MEN1KMT2ACYP2C19LMNACYP3A4 | |
| SCHEMBL7140862 | 0.83 | KCNJ11 (0.55) | MEN1KMT2AKCNJ11MAPTALDH1A1 | |
| SCHEMBL7140044 | 0.82 | NPC1 (0.41) | MEN1KMT2ACYP1A2CYP2C19CYP3A4 | |
| SCHEMBL6612213 | 0.82 | KCNJ11 (0.57) | KMT2AKCNJ11ABCC9ABCC8KCNJ8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392655-A2 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2004-03-03 | — | — | EP | claimed |
| JP-2003506355-A | — | — | 2003-02-18 | — | — | JP | claimed |
| WO-2002062762-A2 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | claimed |
| EP-1198456-A2 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2002-04-24 | — | — | EP | claimed |
| WO-2001009096-A2 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2001-02-08 | — | — | WO | claimed |
| EP-1392655-A2 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002062762-A2 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | disclosed |
| EP-1198456-A2 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2002-04-24 | — | — | EP | disclosed |
| WO-2001009096-A2 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2001-02-08 | — | — | WO | disclosed |