Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6610072 | 0.82 | HPGD (0.48) | HPGDPOLBSMN1; SMN2ALOX15KMT2A | |
| SCHEMBL6610804 | 0.77 | PDE4A (0.39) | HPGDSMN1; SMN2KMT2APDE4APDE4B | |
| SCHEMBL6612284 | 0.75 | CYP1A2 (0.48) | HPGDSMN1; SMN2KMT2APDE4APDE4B | |
| SCHEMBL6616317 | 0.75 | ALDH1A1 (0.45) | HPGDPOLBSMN1; SMN2KMT2APDE4A | |
| SCHEMBL6615636 | 0.73 | NPC1 (0.40) | HPGDPOLBSMN1; SMN2KMT2APDE4A | |
| SCHEMBL6613895 | 0.73 | ALDH1A1 (0.45) | HPGDSMN1; SMN2ALOX15KMT2APDE4A | |
| SCHEMBL6612753 | 0.72 | ALDH1A1 (0.46) | HPGDPOLBSMN1; SMN2KMT2ALMNA | |
| SCHEMBL6610452 | 0.72 | NPC1 (0.38) | HPGDSMN1; SMN2KMT2APDE4APDE4B | |
| SCHEMBL6614342 | 0.71 | ALDH1A1 (0.45) | HPGDSMN1; SMN2KMT2ANPC1ALDH1A1 | |
| SCHEMBL6611896 | 0.68 | LMNA (0.45) | HPGDPOLBSMN1; SMN2KMT2APDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252157-B1 | PYRIMIDINE CARBOXAMIDES USEFUL AS INHIBITORS OF PDE4 ISOZYMES | PFIZER PROD INC (US) | 2004-06-23 | — | — | EP | claimed |