Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4088527 | 0.89 | GAA (0.43) | MEN1KMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL4088792 | 0.86 | RECQL (0.57) | MEN1KMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6616220 | 0.78 | RECQL (0.50) | MEN1KMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6610678 | 0.78 | CHEK1 (0.40) | ALDH1A1KDM4EMAPTALOX15LMNA | |
| SCHEMBL14679555 | 0.73 | TRPA1 (0.40) | — | |
| SCHEMBL28009247 | 0.72 | KMT2A (0.59) | MEN1KMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL3510937 | 0.72 | SMN1; SMN2 (0.61) | MEN1KMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL10653177 | 0.70 | SMN1; SMN2 (0.56) | MEN1KMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL5803807 | 0.70 | SMN1; SMN2 (0.56) | MEN1KMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL8351467 | 0.69 | ALDH1A1 (0.44) | MEN1KMT2ARAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1261600-B1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE ENZYME IKK-2 | ASTRAZENECA AB (SE) | 2004-05-06 | — | — | EP | disclosed |