Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 8/20 | 0.43 |
| ▸ | GIPR | P48546 | 6/20 | 0.43 |
| ▸ | NAMPT | P43490 | 3/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6615997 | 0.93 | GCGR (0.45) | GCGRGIPRNAMPTABL1TRPV1 | |
| SCHEMBL6619787 | 0.92 | MAPK14 (0.41) | NAMPT | |
| SCHEMBL6618517 | 0.91 | KDM4E (0.45) | NAMPT | |
| SCHEMBL6614784 | 0.90 | POLB (0.41) | CTNNB1TCF7L2 | |
| SCHEMBL6608341 | 0.88 | POLB (0.44) | NAMPT | |
| SCHEMBL6617916 | 0.88 | NAMPT (0.44) | NAMPT | |
| SCHEMBL6619980 | 0.87 | GCGR (0.45) | GCGRGIPRNAMPTABL1CTNNB1 | |
| SCHEMBL6619043 | 0.86 | SLC2A1 (0.42) | GCGRGIPRNAMPTABL1TRPV1 | |
| SCHEMBL6616422 | 0.86 | NAMPT (0.45) | GCGRGIPRNAMPTABL1TRPV1 | |
| SCHEMBL6617712 | 0.86 | RAF1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | disclosed |