Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 4/20 | 0.45 |
| ▸ | NAMPT | P43490 | 3/20 | 0.45 |
| ▸ | GIPR | P48546 | 3/20 | 0.45 |
| ▸ | ABL1 | P00519 | 3/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6619980 | 0.94 | GCGR (0.45) | GCGRNAMPTGIPRABL1CTNNB1 | |
| SCHEMBL6616422 | 0.93 | NAMPT (0.45) | GCGRNAMPTGIPRABL1CTNNB1 | |
| SCHEMBL6614050 | 0.93 | GCGR (0.43) | GCGRNAMPTGIPRABL1CTNNB1 | |
| SCHEMBL6615756 | 0.92 | NAMPT (0.42) | GCGRNAMPTGIPRABL1EPHX2 | |
| SCHEMBL6615889 | 0.90 | TRPV1 (0.45) | GCGRNAMPTGIPRABL1EPHX2 | |
| SCHEMBL6616573 | 0.88 | NR1H4 (0.41) | NAMPTEPHX2NR1H4TRPV1CYP1A2 | |
| SCHEMBL6615051 | 0.88 | SCN2A (0.42) | GCGRNAMPTGIPRABL1TRPV1 | |
| SCHEMBL6613507 | 0.88 | MAPT (0.42) | NAMPTCTNNB1TCF7L2SMN1; SMN2ALDH1A1 | |
| SCHEMBL6620182 | 0.88 | MAPT (0.47) | NAMPTSMN1; SMN2ALDH1A1HPGDMEN1 | |
| SCHEMBL6616947 | 0.86 | SSTR3 (0.43) | NAMPTCTNNB1TCF7L2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |