Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | FBP1 | P09467 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31553322 | 0.72 | PIM1 (0.40) | PIM1ALDH1A1KDM4ESMN1; SMN2CYP2A6 | |
| SCHEMBL31553324 | 0.72 | PIM1 (0.40) | PIM1ALDH1A1KDM4ESMN1; SMN2CYP2A6 | |
| SCHEMBL21623963 | 0.72 | KDM4E (0.45) | PIM1ALDH1A1KDM4ESMN1; SMN2CYP2A6 | |
| SCHEMBL31556855 | 0.72 | KDM4E (0.45) | PIM1ALDH1A1KDM4ESMN1; SMN2CYP2A6 | |
| SCHEMBL5709843 | 0.71 | KDM4E (0.39) | PIM1ALDH1A1KDM4ESMN1; SMN2CYP2A6 | |
| SCHEMBL11889611 | 0.69 | AXL (0.34) | PIM1ALDH1A1KDM4ESMN1; SMN2CYP2A6 | |
| SCHEMBL4880326 | 0.68 | NOTUM (0.44) | ALDH1A1MAPTLMNAPOLBHTT | |
| SCHEMBL7902 | 0.68 | ALDH1A1 (0.47) | ALDH1A1KDM4ESMN1; SMN2MAPTMEN1 | |
| SCHEMBL11545484 | 0.66 | CYP1A2 (0.34) | CYP1A2CYP2C9 | |
| SCHEMBL3624554 | 0.66 | PIM1 (0.43) | PIM1ALDH1A1KDM4ESMN1; SMN2CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040220232-A1 | Novel process for making 5-substituted pyrazoles | PHAMACIA CORPORATION | 2004-11-04 | — | — | US | disclosed |
| US-6750338-B2 | 5-AMINO- AND 5-THIO- SUBSTITUTED; PREPARED FROM A METHYLENEDITHIETANE INTERMEDIATE | PHARMACIA CORPORATION | 2004-06-15 | — | — | US | disclosed |
| EP-1131318-B1 | PROCESS FOR MAKING 5-SUBSTITUTED PYRAZOLES USING DITHIETANES | SEARLE LLC (US) | 2004-03-24 | — | — | EP | disclosed |
| EP-1380584-A1 | Process for making 5-substituted pyrazoles using dithietanes | G.D. SEARLE & CO. (US) | 2004-01-14 | — | — | EP | disclosed |
| US-20030135057-A1 | Novel process for making 5-substituted pyrazoles | PHARMACIA CORPORATION | 2003-07-17 | — | — | US | disclosed |
| US-6482955-B2 | ORGANOMETALLIC REAGENT REACTED WITH AN ACTIVATED CARBOXYLIC ACID TO PRODUCE A KETONE REACTED WITH CARBON DISULFIDE AND DIHALOMETHANE, FURTHER REACTING THE DITHIETANE PRODUCT WITH A SECONDARY AMINE, AND CONDENSING THE THIOAMIDE WITH HYDRAZINE | PHARMACIA CORPORATION | 2002-11-19 | — | — | US | disclosed |
| US-20020115868-A1 | Novel process for making 5-substituted pyrazoles | PHARMACIA CORPORATION | 2002-08-22 | — | — | US | disclosed |
| US-6342608-B1 | REACTING ORGANOMETALLIC REAGENT WITH ACTIVATED CARBOXYLIC ACID TO FORM KETONE, TREATING WITH MIXTURE OF CARBON DISULFIDE AND DIHALOMETHANE TO FORM DITHIETANE, REACTING WITH HYDRAZINE DERIVATIVE TO FORM THIOL-SUBSTITUTED PYRAZOLE, ALKYLATING | G.D. SEARLE & COMPANY | 2002-01-29 | — | — | US | disclosed |
| EP-1131318-A1 | PROCESS FOR MAKING 5-SUBSTITUTED PYRAZOLES USING DITHIETANES | G.D. SEARLE & CO. (US) | 2001-09-12 | — | — | EP | disclosed |
| US-6242612-B1 | Process for making substituted pyrazoles | G. D. SEARLE & CO. | 2001-06-05 | — | — | US | disclosed |
| US-6143892-A | REACTING AN ORGANOMETALLIC COMPOUND WITH AN ACTIVATED FORM OF CARBOXYLIC ACID TO FORM A KETONE, TREATING KETONE WITH A MIXTURE OF CARBON DISULFIDE AND DIHALOMETHANE, AMIDATING WITH AMINE, CONDENSING THE THIOAMIDE WITH HYDRAZINE OR DERIVATIVE | G. D. SEARLE & CO. (US) | 2000-11-07 | — | — | US | disclosed |
| WO-2000031072-A1 | PROCESS FOR MAKING 5-SUBSTITUTED PYRAZOLES USING DITHIETANES | G.D. SEARLE & CO. (US) | 2000-06-02 | — | — | WO | disclosed |
| CN-1033806-C | Herbicidal composition | DOWELANCO (US) | 1997-01-15 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040220232-A1 | Novel process for making 5-substituted pyrazoles | MAP3K5, MAP4K2, MAPKAPK2 | PIM1 975/4885ALDH1A1 1316/4885KDM4E 2170/4885 |
| US-20020115868-A1 | Novel process for making 5-substituted pyrazoles | MAP3K5, MAP4K2, MAPKAPK2 | PIM1 975/4885ALDH1A1 1316/4885KDM4E 2170/4885 |
| US-20030135057-A1 | Novel process for making 5-substituted pyrazoles | MAP3K5, MAP4K2, MAPKAPK2 | PIM1 975/4885ALDH1A1 1316/4885KDM4E 2170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.