Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.33 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.32 |
| ▸ | NPY2R | P49146 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6683269 | 0.87 | LMNA (0.33) | LMNAKMT2AMEN1GAAALDH1A1 | |
| SCHEMBL6617950 | 0.87 | LMNA (0.47) | LMNAKMT2AMEN1GAAALDH1A1 | |
| SCHEMBL6617610 | 0.86 | KMT2A (0.40) | LMNAKMT2AMEN1GAACYP1A2 | |
| SCHEMBL6616066 | 0.85 | KMT2A (0.39) | LMNAKMT2AMEN1GAAALDH1A1 | |
| SCHEMBL6619894 | 0.85 | KMT2A (0.39) | LMNAKMT2AMEN1GAAALDH1A1 | |
| SCHEMBL6620487 | 0.85 | CHRNA7 (0.37) | LMNAKMT2AMEN1ALDH1A1CHRNA7 | |
| SCHEMBL6618534 | 0.85 | NPY2R (0.38) | LMNAKMT2AMEN1GAACYP1A2 | |
| SCHEMBL6621376 | 0.84 | KMT2A (0.39) | LMNAKMT2AMEN1GAAALDH1A1 | |
| SCHEMBL6617829 | 0.83 | ALDH1A1 (0.39) | LMNAKMT2AGAAALDH1A1POLB | |
| SCHEMBL6617170 | 0.83 | KMT2A (0.45) | LMNAKMT2AMEN1GAACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | disclosed |