Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 4/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 3/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | WDR5 | P61964 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618105 | 0.94 | CCR2 (0.40) | LMNASMN1; SMN2MAPTHPGDKDM4E | |
| SCHEMBL6619787 | 0.93 | MAPK14 (0.41) | LMNASMN1; SMN2MAPTALDH1A1POLB | |
| SCHEMBL6616425 | 0.89 | NAMPT (0.40) | MAPTHPGDKDM4EALDH1A1POLB | |
| SCHEMBL6614784 | 0.89 | POLB (0.41) | MAPTALDH1A1POLBMAPK14 | |
| SCHEMBL6608341 | 0.89 | POLB (0.44) | MAPTHPGDKDM4EALDH1A1POLB | |
| SCHEMBL6614045 | 0.89 | EPHX2 (0.41) | LMNASMN1; SMN2MAPTTP53MEN1 | |
| SCHEMBL6616443 | 0.88 | CRACR2A (0.42) | MAPTALDH1A1CCR3HRH3CHRM1 | |
| SCHEMBL6619399 | 0.88 | MAPT (0.47) | LMNASMN1; SMN2MAPTHPGDALDH1A1 | |
| SCHEMBL6660284 | 0.88 | ACKR3 (0.42) | LMNASMN1; SMN2MAPTPOLBTP53 | |
| SCHEMBL6618517 | 0.88 | KDM4E (0.45) | LMNASMN1; SMN2MAPTHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |