Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6611117 | 0.91 | MAPT (0.41) | MAPTALDH1A1SMN1; SMN2KDM4ENPSR1 | |
| SCHEMBL6613107 | 0.90 | MAPT (0.44) | MAPTALDH1A1SMN1; SMN2KDM4ENPSR1 | |
| SCHEMBL6610923 | 0.89 | HSD17B10 (0.42) | MAPTALDH1A1SMN1; SMN2KDM4ENPSR1 | |
| SCHEMBL6616178 | 0.89 | SMN1; SMN2 (0.47) | MAPTALDH1A1SMN1; SMN2NPSR1MEN1 | |
| SCHEMBL6613841 | 0.87 | ALDH1A1 (0.39) | MAPTALDH1A1SMN1; SMN2KDM4ENPSR1 | |
| SCHEMBL6614360 | 0.87 | MEN1 (0.41) | MAPTALDH1A1SMN1; SMN2NPSR1MEN1 | |
| SCHEMBL6615199 | 0.87 | MAPK1 (0.47) | MAPTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6615418 | 0.86 | MAPT (0.38) | MAPTALDH1A1SMN1; SMN2KDM4ENPSR1 | |
| SCHEMBL6611013 | 0.86 | MAPT (0.39) | MAPTALDH1A1SMN1; SMN2KDM4ENPSR1 | |
| SCHEMBL6609861 | 0.86 | MAPT (0.41) | MAPTALDH1A1SMN1; SMN2KDM4ENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463724-A1 | PYRROLIDONE CARBOXAMIDES | Actelion Pharmaceuticals Ltd. (CH) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003059905-A1 | PYRROLIDONE CARBOXAMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2003-07-24 | — | — | WO | disclosed |