Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | AVPR2 | P30518 | 3/20 | 0.38 |
| ▸ | IDH1 | O75874 | 9/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6616672 | 0.82 | AVPR2 (0.49) | AVPR2IDH1 | |
| SCHEMBL6615939 | 0.82 | AVPR2 (0.62) | AVPR2 | |
| SCHEMBL7508188 | 0.79 | IDH1 (0.39) | AVPR2IDH1MAPK14MAPK13MAPK12 | |
| SCHEMBL7392203 | 0.76 | MAPT (0.36) | KDM4EAVPR2IDH1POLBMAPT | |
| SCHEMBL7510097 | 0.74 | AVPR2 (0.41) | AVPR2 | |
| SCHEMBL7451415 | 0.74 | AVPR2 (0.39) | AVPR2IDH1AKT1 | |
| SCHEMBL7505774 | 0.74 | P2RX3 (0.34) | AVPR2IDH1 | |
| SCHEMBL7319398 | 0.74 | MAPK14 (0.34) | KDM4EMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6615066 | 0.73 | AVPR2 (0.64) | AVPR2IDH1 | |
| SCHEMBL7390951 | 0.73 | NPC1 (0.41) | KDM4EPOLBMAPTTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000059-B1 | TRICYCLIC VASOPRESSIN AGONISTS | WYETH CORP (US) | 2004-09-29 | — | — | EP | disclosed |
| US-6194407-B1 | INCONTINENCE | AMERICAN HOME PRODUCTS CORPORATION | 2001-02-27 | — | — | US | disclosed |
| US-6090803-A | ANTIDIABETIC AGENTS; INCONTINENCE | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-07-18 | — | — | US | disclosed |
| EP-1000059-A1 | TRICYCLIC VASOPRESSIN AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999006403-A1 | TRICYCLIC VASOPRESSIN AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-02-11 | — | — | WO | disclosed |