Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 4/20 | 0.41 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.41 |
| ▸ | RORB | Q92753 | 1/20 | 0.33 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.31 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
| ▸ | CTSC | P53634 | 1/20 | 0.30 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7451415 | 0.84 | AVPR2 (0.39) | AVPR2AVPR1ARORB | |
| SCHEMBL7508188 | 0.82 | IDH1 (0.39) | AVPR2AVPR1ARORB | |
| SCHEMBL6615566 | 0.81 | AVPR2 (0.61) | AVPR2AVPR1ARORBPAK1 | |
| SCHEMBL7505774 | 0.75 | P2RX3 (0.34) | AVPR2AVPR1AP2RX3 | |
| SCHEMBL6615080 | 0.74 | KDM4E (0.38) | AVPR2 | |
| SCHEMBL7392203 | 0.69 | MAPT (0.36) | AVPR2 | |
| SCHEMBL7390951 | 0.69 | NPC1 (0.41) | — | |
| SCHEMBL7396733 | 0.67 | RAB9A (0.40) | — | |
| SCHEMBL6616850 | 0.66 | AVPR2 (0.62) | AVPR2AVPR1A | |
| SCHEMBL6616672 | 0.66 | AVPR2 (0.49) | AVPR2AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149103-A1 | THIENYLBENZOYLBENZAZEPINES AS VASOPRESSIN AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-31 | — | — | EP | claimed |
| US-6297234-B1 | Arylthiophene vasopressin agonists | AMERICAN HOME PRODUCTS CORPORATION | 2001-10-02 | — | — | US | claimed |
| US-6268360-B1 | URINATION DELAY | AMERICAN HOME PRODUCTS CORPORATION | 2001-07-31 | — | — | US | claimed |
| WO-2000046227-A1 | THIENYLBENZOYLBENZAZEPINES AS VASOPRESSIN AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-08-10 | — | — | WO | claimed |
| EP-1149103-A1 | THIENYLBENZOYLBENZAZEPINES AS VASOPRESSIN AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-31 | — | — | EP | disclosed |
| US-6297234-B1 | Arylthiophene vasopressin agonists | AMERICAN HOME PRODUCTS CORPORATION | 2001-10-02 | — | — | US | disclosed |
| US-6268360-B1 | URINATION DELAY | AMERICAN HOME PRODUCTS CORPORATION | 2001-07-31 | — | — | US | disclosed |
| WO-2000046227-A1 | THIENYLBENZOYLBENZAZEPINES AS VASOPRESSIN AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-08-10 | — | — | WO | disclosed |